| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.[1][2][3] Function The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas, associated with lymph node metastasis, and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas.[3] References1. ^{{cite journal | vauthors = Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y | title = Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q | journal = Cancer Res | volume = 56 | issue = 7 | pages = 1629–34 | date = May 1996 | pmid = 8603412 | pmc = | doi = }}
2. ^{{cite journal | vauthors = Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y | title = Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32 | journal = Genes Chromosomes Cancer | volume = 27 | issue = 2 | pages = 169–76 | date = Feb 2000 | pmid = 10612805 | pmc = | doi = 10.1002/(SICI)1098-2264(200002)27:2<169::AID-GCC8>3.0.CO;2-M }}
3. ^1 {{cite web | title = Entrez Gene: DEC1 deleted in esophageal cancer 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50514| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors = Qian Y, Zhang J, Yan B, Chen X | title = DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. | journal = J. Biol. Chem. | volume = 283 | issue = 5 | pages = 2896–905 | year = 2008 | pmid = 18025081 | doi = 10.1074/jbc.M708624200 | pmc = 4118587 }}
- {{cite journal | vauthors = Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML | title = Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. | journal = Int. J. Cancer | volume = 122 | issue = 3 | pages = 587–94 | year = 2008 | pmid = 17943723 | doi = 10.1002/ijc.23144 }}
- {{cite journal | vauthors = Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B | title = The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. | journal = Oncogene | volume = 25 | issue = 23 | pages = 3296–306 | year = 2006 | pmid = 16462771 | doi = 10.1038/sj.onc.1209363 | pmc = 4114758 }}
- {{cite journal | vauthors = Preusser M, Birner P, Ambros IM, Ambros PF, Budka H, Harris AL, Hainfellner JA | title = DEC1 expression in 1p-aberrant oligodendroglial neoplasms. | journal = Histol. Histopathol. | volume = 20 | issue = 4 | pages = 1173–7 | year = 2006 | pmid = 16136500 | doi = }}
- {{cite journal | vauthors = Yang L, Leung AC, Ko JM, Lo PH, Tang JC, Srivastava G, Oshimura M, Stanbridge EJ, Daigo Y, Nakamura Y, Tang CM, Lau KW, Law S, Lung ML | title = Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma. | journal = Oncogene | volume = 24 | issue = 4 | pages = 697–705 | year = 2005 | pmid = 15580306 | doi = 10.1038/sj.onc.1208179 }}
- {{cite journal | vauthors = Wong VC, Ko JM, Qi RZ, Li PJ, Wang LD, Li JL, Chan YP, Chan KW, Stanbridge EJ, Lung ML | title = Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis. | journal = British Journal of Cancer | volume = 104 | issue = 5 | pages = 841–9 | date = Mar 1, 2011 | pmid = 21326238 | doi = 10.1038/bjc.2011.25 | pmc=3048215}}
- {{cite journal | vauthors = Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML | title = Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. | journal = International Journal of Cancer | volume = 122 | issue = 3 | pages = 587–94 | date = Feb 1, 2008 | pmid = 17943723 | doi = 10.1002/ijc.23144 }}
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