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词条 DEDD
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Death effector domain containing protein is a protein that in humans is encoded by the DEDD gene.[1][2][3]

Function

This gene encodes a protein that contains a death effector domain (DED). DED is a protein–protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.[3]

Interactions

DEDD has been shown to interact with:

  • CFLAR,[5][6]
  • Caspase 8,[4][5][6] and
  • FADD.[1][7]

References

1. ^1 {{cite journal | vauthors = Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME | title = DEDD, a novel death effector domain-containing protein, targeted to the nucleolus | journal = EMBO J | volume = 17 | issue = 20 | pages = 5974–86 | date = Dec 1998 | pmid = 9774341 | pmc = 1170924 | doi = 10.1093/emboj/17.20.5974 }}
2. ^{{cite journal | vauthors = Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ | title = DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells | journal = Endocrinology | volume = 139 | issue = 12 | pages = 4839–48 | date = Dec 1998 | pmid = 9832420 | pmc = | doi = 10.1210/en.139.12.4839 }}
3. ^1 {{cite web | title = Entrez Gene: DEDD death effector domain containing| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9191| accessdate = }}
4. ^1 {{cite journal | vauthors = Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES | title = Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC | journal = Cell Death Differ. | volume = 9 | issue = 4 | pages = 439–47 | date = Apr 2002 | pmid = 11965497 | doi = 10.1038/sj/cdd/4401038 }}
5. ^{{cite journal | vauthors = Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME | title = DEDD, a novel death effector domain-containing protein, targeted to the nucleolus | journal = EMBO J. | volume = 17 | issue = 20 | pages = 5974–86 | date = Oct 1998 | pmid = 9774341 | pmc = 1170924 | doi = 10.1093/emboj/17.20.5974 }}
6. ^{{cite journal | vauthors = Alcivar A, Hu S, Tang J, Yang X | title = DEDD and DEDD2 associate with caspase-8/10 and signal cell death | journal = Oncogene | volume = 22 | issue = 2 | pages = 291–7 | date = Jan 2003 | pmid = 12527898 | doi = 10.1038/sj.onc.1206099 }}
7. ^1 {{cite journal | vauthors = Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC | title = Identification and characterization of DEDD2, a death effector domain-containing protein | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7501–8 | date = Mar 2002 | pmid = 11741985 | doi = 10.1074/jbc.M110749200 }}
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Further reading

{{Refbegin| 2}}
  • {{cite journal | vauthors = Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E | title = Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation | journal = Int. J. Cancer | volume = 115 | issue = 3 | pages = 412–8 | year = 2005 | pmid = 15688372 | doi = 10.1002/ijc.20857 }}
  • {{cite journal | vauthors = Alcivar A, Hu S, Tang J, Yang X | title = DEDD and DEDD2 associate with caspase-8/10 and signal cell death | journal = Oncogene | volume = 22 | issue = 2 | pages = 291–7 | year = 2003 | pmid = 12527898 | doi = 10.1038/sj.onc.1206099 }}
  • {{cite journal | vauthors = Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME | title = DEDD regulates degradation of intermediate filaments during apoptosis | journal = J. Cell Biol. | volume = 158 | issue = 6 | pages = 1051–66 | year = 2002 | pmid = 12235123 | pmc = 2173221 | doi = 10.1083/jcb.200112124 }}
  • {{cite journal | vauthors = Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES | title = Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC | journal = Cell Death Differ. | volume = 9 | issue = 4 | pages = 439–47 | year = 2002 | pmid = 11965497 | doi = 10.1038/sj/cdd/4401038 }}
  • {{cite journal | vauthors = Schickling O, Stegh AH, Byrd J, Peter ME | title = Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription | journal = Cell Death Differ. | volume = 8 | issue = 12 | pages = 1157–68 | year = 2002 | pmid = 11753564 | doi = 10.1038/sj.cdd.4400928 }}
  • {{cite journal | vauthors = Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC | title = Identification and characterization of DEDD2, a death effector domain-containing protein | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7501–8 | year = 2002 | pmid = 11741985 | doi = 10.1074/jbc.M110749200 }}
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