| 词条 | Delapril |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 444593478 | IUPAC_name = 2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid | image = Delapril.svg | width = 222 | tradename = | Drugs.com = {{drugs.com|international|delapril}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 83435-66-9 | ATC_prefix = C09 | ATC_suffix = AA12 | ATC_supplemental = | PubChem = 5362116 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = W77UAL9THI | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2106126 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07781 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4514931 | SMILES = O=C(OCC)[C@@H](N[C@H](C(=O)N(CC(=O)O)C2Cc1ccccc1C2)C)CCc3ccccc3 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C26H32N2O5/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30)/t18-,23-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = WOUOLAUOZXOLJQ-MBSDFSHPSA-N | C=26 | H=32 | N=2 | O=5 | molecular_weight = 452.542 g/mol }}Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug[1] in some European and Asian countries but not in America.[2] It is taken orally, available in 15 mg and 30 mg tablets.[3] MechanismDelapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.[4] References1. ^{{Cite journal | last1 = Otero | first1 = M. L. | title = Manidipine-delapril combination in the management of hypertension | journal = Vascular Health and Risk Management | volume = 3 | issue = 3 | pages = 255–263 | year = 2007 | pmid = 17703633 | pmc = 2293964}} {{ACE inhibitors}}{{Angiotensin receptor modulators}}{{cardiovascular-drug-stub}}2. ^Drugs.com: [https://www.drugs.com/international/delapril.html Delapril] 3. ^{{Cite web|url=http://cursoenarm.net/UPTODATE/contents/mobipreview.htm?16/0/16396?source=HISTORY|title=cursoenarm.net/UPTODATE/contents/mobipreview.htm?16/0/16396?source=HISTORY|website=cursoenarm.net|access-date=2016-08-28}} 4. ^{{Cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/delapril#section=Pharmacology-and-Biochemistry|title=DELAPRIL {{!}} C26H32N2O5 - PubChem|last=Pubchem|website=pubchem.ncbi.nlm.nih.gov|access-date=2016-08-28}} 7 : ACE inhibitors|Acetic acids|Enantiopure drugs|Ethyl esters|Indanes|Prodrugs|Propionamides |
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