| 词条 | Demoxepam |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 460769285 | IUPAC_name = 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one-4-oxide | image = Demoxepam.svg | width = 222 | tradename = | legal_status = | bioavailability = | metabolism = | elimination_half-life = 35–40 hours | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 963-39-3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C15H11ClN2O2/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)18(20)9-14(19)17-13/h1-8H,9H2,(H,17,19) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = GGRWZBVSUZZMKS-UHFFFAOYSA-N | PubChem = 13756 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1597677 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 10441314 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 8X1XP5M0SB | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D02600 | C=15 | H=11 | Cl=1 | N=2 | O=2 | molecular_weight = 286.713 | smiles = ClC1=CC2=C(NC(C[N+]([O-])=C2C3=CC=CC=C3)=O)C=C1 }} Demoxepam[1] is a drug which is a benzodiazepine derivative. It is a metabolite of chlordiazepoxide and has anticonvulsant properties[2][3] and presumably other characteristic benzodiazepine properties. SynthesisDemoxepam is also an intermediate in the synthesis of oxazepam; it is also used in one of the syntheses of medazepam. It can be considered directly analogous/synonoymous with the synthesis of chlordiazepoxide, with the exception that instead of methylamine, hydroxide ion is the choice of base; here acid is not used for the cyclodehydration step though. See also
References1. ^US Patent 3136815 {{Benzodiazepines}}{{GABAAR PAMs}}{{sedative-stub}}2. ^{{Cite web | url = http://www.psychotropics.dk/moleculeView/default.aspx?ID=1438&Catalogtype=A&ChapterID=1&Thissortorder=35 | title = nortetrazepam | accessdate = 7 December 2009 | year = 2003 | publisher = psychotropics.dk }} 3. ^{{Cite journal |author= |title=LIST OF INTERNATIONAL NON-PROPRIETARY NAMES (INNS), PROVIDED FOR PHARMACEUTICAL SUBSTANCES BY THE WORLD HEALTH ORGANIZATION, WHICH ARE FREE OF DUTY |journal=Official Journal of the European Communities |format=PDF |publisher=eur-lex.europa.eu |date=23 October 2001 |accessdate=7 December 2009 |url=http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2001:279:0767:0876:EN:PDF }} 4 : Benzodiazepines|Chloroarenes|GABAA receptor positive allosteric modulators|Lactams |
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