| 词条 | Denopamine |
| 释义 |
| IUPAC_name = 4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol | image = Denopamine.svg | width = 275 | tradename = | Drugs.com = {{drugs.com|international|denopamine}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = ℞-only (JP) | routes_of_administration = Oral (tablets) | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 71771-90-9 | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | PubChem = 71754 | ChEMBL = 493682 | IUPHAR_ligand = 534 | DrugBank = | ChemSpiderID = 64795 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = V5F60UPD8P | KEGG = D02614 | chemical_formula = | C=18 | H=23 | N=1 | O=4 | molecular_weight = 317.37 g/mol | smiles = O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C }}Denopamine (INN) is a cardiotonic drug which acts as a β1 adrenergic receptor agonist.[1] It is used in the treatment of angina[2] and may also have potential uses in the treatment of congestive heart failure[3] and for clearing pulmonary oedema.[4] It is marketed in Japan under the brand name Kalgut (カルグート) and available as tablets of 5 and 10 mg, and 5% fine granules.[5] References1. ^{{cite journal | pmid = 12487507 | volume=18 | issue=7 | title=Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator | year=2002 | journal=Curr Med Res Opin | pages=407–13 | last1 = Ishide | first1 = T | doi=10.1185/030079902125001119}} {{Adrenergic agonists}}{{pharma-stub}}2. ^{{cite journal | last1 = Nakajima | first1 = D | last2 = Negoro | first2 = N | last3 = Nakaboh | first3 = A | last4 = Nakakoji | first4 = T | last5 = Hoshiga | first5 = M | last6 = Nariyama | first6 = J | last7 = Ishihara | first7 = T | last8 = Hanafusa | first8 = T | date = Apr 2006 | title = Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment | url = | journal = International Journal of Cardiology | volume = 108 | issue = 2| pages = 281–3 | doi = 10.1016/j.ijcard.2005.03.012 | pmid = 15913812 }} 3. ^{{cite journal | last1 = Nishio | first1 = R | last2 = Matsumori | first2 = A | last3 = Shioi | first3 = T | last4 = Wang | first4 = W | last5 = Yamada | first5 = T | last6 = Ono | first6 = K | last7 = Sasayama | first7 = S | date = Sep 1998 | title = Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart | url = | journal = Journal of the American College of Cardiology | volume = 32 | issue = 3| pages = 808–15 | doi = 10.1016/S0735-1097(98)00314-3 | pmid = 9741531 }} 4. ^{{cite journal | last1 = Sakuma | first1 = T | last2 = Hida | first2 = M | last3 = Nambu | first3 = Y | last4 = Osanai | first4 = K | last5 = Toga | first5 = H | last6 = Takahashi | first6 = K | last7 = Ohya | first7 = N | last8 = Inoue | first8 = M | last9 = Watanabe | first9 = Y | date = Feb 2001 | title = Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs | url = | journal = Japanese Journal of Pharmacology | volume = 85 | issue = 2| pages = 161–6 | doi = 10.1254/jjp.85.161 | pmid = 11286398 }} 5. ^{{cite web|title=Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information|url=http://medical.mt-pharma.co.jp/di/file/dc/kal.pdf|publisher=Mitsubishi Tanabe Pharma Corporation|accessdate=6 March 2016|language=Japanese}} 5 : Alcohols|Beta1-adrenergic agonists|Phenethylamines|Phenol ethers|Phenols |
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