“Deoxyadenosine kinase”的意思、由来-开放百科全书

词条

Deoxyadenosine kinase

释义

Structural studies
References

{{enzyme
| Name = deoxyadenosine kinase
| EC_number = 2.7.1.76
| CAS_number = 37278-12-9
| IUBMB_EC_number = 2/7/1/76
| GO_code = 0004136
| image =
| width =
| caption =
}}

In enzymology, a deoxyadenosine kinase ({{EC number|2.7.1.76}}) is an enzyme that catalyzes the chemical reaction

ATP + deoxyadenosine ADP + dAMP

Thus, the two substrates of this enzyme are ATP and deoxyadenosine, whereas its two products are ADP and dAMP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:deoxyadenosine 5'-phosphotransferase. This enzyme is also called purine-deoxyribonucleoside kinase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|2JAQ}}.

References

{{cite journal | vauthors = Chang CH, Brockman RW, Bennett LL | date = 1982 | title = Purification and some properties of a deoxyribonucleoside kinase from L1210 cells | journal = Cancer Res. | volume = 42 | pages = 3033–9 | pmid = 6284353 | issue = 8 }}
{{cite journal | vauthors = Krygier V, Momparler RL | date = 1968 | title = The regulatory properties of deoxyadenosine kinase | journal = Biochim. Biophys. Acta | volume = 161 | pages = 578–80 | pmid = 5667299 | issue = 2 | doi=10.1016/0005-2787(68)90139-1}}

2 : EC 2.7.1|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。