| 词条 | Deoxypyridinoline |
| 释义 |
| ImageFile = Deoxypyridinoline.svg | ImageSize = 250 |Section1={{Chembox Identifiers | CASNo = 83462-55-9 | PubChem = 105071 | ChemSpiderID = 94801 }} |Section2={{Chembox Properties | C=18 | H=28 | N=4 | O=7 | MolarMass = 412.43752 g mol−1 }} }}Deoxypyridinoline, also called D-Pyrilinks, Pyrilinks-D, or deoxyPYD, is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones.[1] It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclastic activity. It is measured in urine tests and is used along with other bone markers such as alkaline phosphatase, osteocalcin, and N-terminal telopeptide to diagnose bone diseases such as postmenopausal osteoporosis, bone metastasis, and Paget's disease, furthermore, it has been useful in monitoring treatments that contain bone-active agents such as estrogens and bisphosphonates. [1] Certain studies have attempted to generate a standardization of Deoxypyridinoline via an individual molar absorptivity value at acid and neutrality pH. The result was 5160 and 5290 L mol−1 cm−1 respectively.[2] References1. ^1 {{cite journal|last=Rubinacci|first=A|author2=Melzi, R|author3=Zampino, M|author4=Soldarini, A|author5=Villa, I|title=Total and free deoxypyridinoline after acute osteoclast activity inhibition.|journal=Clinical Chemistry|year=1999|volume=45|issue=9|pages=1510–6|pmid=10471654}} 2. ^{{cite journal|last=Robins|first=SP|author2=Duncan, A |author3=Wilson, N |author4= Evans, BJ |title=Standardization of pyridinium crosslinks, pyridinoline and deoxypyridinoline, for use as biochemical markers of collagen degradation.|journal=Clinical Chemistry|year=1996|volume=42|issue=10|pages=1621–6|pmid=8855145}} 1 : Amino acids |
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