“DGKQ”的意思、由来-开放百科全书

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.^[3]

References

1. ^{{cite journal | vauthors = Endele S, Zabel B, Winterpacht A | title = Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3 | journal = Genomics | volume = 33 | issue = 1 | pages = 145–6 |date=Jun 1996 | pmid = 8617502 | pmc = | doi = 10.1006/geno.1996.0174 }}
2. ^{{cite journal | vauthors = Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ | title = Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain | journal = J Biol Chem | volume = 272 | issue = 16 | pages = 10422–8 |date=May 1997 | pmid = 9099683 | pmc = | doi =10.1074/jbc.272.16.10422 }}
3. ^¹{{cite web | title = Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1609| accessdate = }}
4. ^{{cite journal |last=Houssa |first=B |author2=de Widt J |author3=Kranenburg O |author4=Moolenaar W H |author5=van Blitterswijk W J |date=Mar 1999 |title=Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA |journal=J. Biol. Chem. |volume=274 |issue=11 |pages=6820–2 | issn = 0021-9258| pmid = 10066731 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.11.6820 }}

Further reading

{{cite journal | vauthors=Sakane F, Kanoh H |title=Molecules in focus: diacylglycerol kinase |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 10 |pages= 1139–43 |year= 1998 |pmid= 9438377 |doi= 10.1016/S1357-2725(97)00037-X}}

{{cite journal | author=Li D |title=Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17 |journal=Mol. Cell. Biol. |volume=27 |issue= 19 |pages= 6669–85 |year= 2008 |pmid= 17664281 |doi= 10.1128/MCB.00355-07 | pmc=2099220 |name-list-format=vanc| author2=Urs AN | author3=Allegood J | display-authors=3 | last4=Leon | first4=A. | last5=Merrill | first5=A. H. | last6=Sewer | first6=M. B. }}

{{cite journal | vauthors=van Baal J, de Widt J, Divecha N, van Blitterswijk WJ |title=Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 9870–8 |year= 2005 |pmid= 15632189 |doi= 10.1074/jbc.M409301200 }}

{{cite journal | author=Tabellini G |title=Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus |journal=Exp. Cell Res. |volume=287 |issue= 1 |pages= 143–54 |year= 2003 |pmid= 12799190 |doi=10.1016/S0014-4827(03)00115-0 |name-list-format=vanc| author2=Bortul R | author3=Santi S | display-authors=3 | last4=Riccio | first4=Massimo | last5=Baldini | first5=Giovanna | last6=Cappellini | first6=Alessandra | last7=Billi | first7=Anna Maria | last8=Berezney | first8=Ronald | last9=Ruggeri | first9=Alessandra }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}}

{{cite journal | author=Houssa B |title=Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 6820–2 |year= 1999 |pmid= 10066731 |doi=10.1074/jbc.274.11.6820 |name-list-format=vanc| author2=de Widt J | author3=Kranenburg O | display-authors=3 | last4=Moolenaar | first4=WH | last5=Van Blitterswijk | first5=WJ }}

{{cite journal | author=Sakane F |title=Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8394–401 |year= 1996 |pmid= 8626538 |doi=10.1074/jbc.271.14.8394 |name-list-format=vanc| author2=Imai S | author3=Kai M | display-authors=3 | last4=Wada | first4=I | last5=Kanoh | first5=H }}

Interactions

References

Further reading