| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.[1][2]The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[2] InteractionsDGKZ has been shown to interact with P110α.[3] References1. ^{{cite journal | vauthors = Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM | title = Molecular cloning and characterization of a novel human diacylglycerol kinase zeta | journal = J Biol Chem | volume = 271 | issue = 17 | pages = 10230–6 |date=Jun 1996 | pmid = 8626588 | pmc = | doi =10.1074/jbc.271.17.10230 }}
2. ^1 {{cite web | title = Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8525| accessdate = }}
3. ^{{cite journal |last=Luo |first=Bai |author2=Prescott Stephen M |author3=Topham Matthew K |date=Oct 2003 |title=Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta |journal=J. Biol. Chem. |volume=278 |issue=41 |pages=39542–7 | issn = 0021-9258| pmid = 12890670 |doi = 10.1074/jbc.M307153200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors=Ding L, Bunting M, Topham MK |title=Alternative splicing of the human diacylglycerol kinase zeta gene in muscle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5519–24 |year= 1997 |pmid= 9159104 |doi=10.1073/pnas.94.11.5519 | pmc=20810 |display-authors=etal|bibcode=1997PNAS...94.5519D}}
- {{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal | vauthors=Topham MK, Bunting M, Zimmerman GA |title=Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta |journal=Nature |volume=394 |issue= 6694 |pages= 697–700 |year= 1998 |pmid= 9716136 |doi= 10.1038/29337 |display-authors=etal|bibcode=1998Natur.394..697T }}
- {{cite journal | vauthors=Liu Z, Chang GQ, Leibowitz SF |title=Diacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulation |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5900–7 |year= 2001 |pmid= 11078732 |doi= 10.1074/jbc.M007311200 }}
- {{cite journal | vauthors=Topham MK, Prescott SM |title=Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism |journal=J. Cell Biol. |volume=152 |issue= 6 |pages= 1135–43 |year= 2001 |pmid= 11257115 |doi=10.1083/jcb.152.6.1135 | pmc=2199204 }}
- {{cite journal | vauthors=Hogan A, Shepherd L, Chabot J |title=Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26526–33 |year= 2001 |pmid= 11352924 |doi= 10.1074/jbc.M104156200 |display-authors=etal}}
- {{cite journal | vauthors=Santos T, Carrasco S, Jones DR |title=Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30300–9 |year= 2002 |pmid= 12015310 |doi= 10.1074/jbc.M200999200 |display-authors=etal}}
- {{cite journal | vauthors=Zhong XP, Hainey EA, Olenchock BA |title=Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 31089–98 |year= 2002 |pmid= 12070163 |doi= 10.1074/jbc.M203818200 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
- {{cite journal | vauthors=Zhong XP, Hainey EA, Olenchock BA |title=Enhanced T cell responses due to diacylglycerol kinase zeta deficiency |journal=Nat. Immunol. |volume=4 |issue= 9 |pages= 882–90 |year= 2003 |pmid= 12883552 |doi= 10.1038/ni958 |display-authors=etal}}
- {{cite journal | vauthors=Luo B, Prescott SM, Topham MK |title=Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 39542–7 |year= 2003 |pmid= 12890670 |doi= 10.1074/jbc.M307153200 }}
- {{cite journal | vauthors=Abramovici H, Hogan AB, Obagi C |title=Diacylglycerol kinase-zeta localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins |journal=Mol. Biol. Cell |volume=14 |issue= 11 |pages= 4499–511 |year= 2004 |pmid= 14551255 |doi= 10.1091/mbc.E03-03-0190 | pmc=266768 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Davidson L, Pawson AJ, López de Maturana R |title=Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11906–16 |year= 2004 |pmid= 14707140 |doi= 10.1074/jbc.M310784200 |display-authors=etal}}
- {{cite journal | vauthors=Luo B, Prescott SM, Topham MK |title=Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism |journal=Cell. Signal. |volume=16 |issue= 8 |pages= 891–7 |year= 2005 |pmid= 15157668 |doi= 10.1016/j.cellsig.2004.01.010 }}
- {{cite journal | vauthors=Avila-Flores A, Santos T, Rincón E, Mérida I |title=Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10091–9 |year= 2005 |pmid= 15632115 |doi= 10.1074/jbc.M412296200 }}
- {{cite journal | vauthors=Los AP, Vinke FP, de Widt J |title=The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta |journal=J. Biol. Chem. |volume=281 |issue= 2 |pages= 858–66 |year= 2006 |pmid= 16286473 |doi= 10.1074/jbc.M502693200 |display-authors=etal}}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
{{refend}}{{gene-11-stub}} |