| 词条 | DHR2 domain |
| 释义 |
DHR2 (DOCK homology region 2), also known as CZH2 or Docker2, is a protein domain of approximately 450-550 amino acids that is present in the DOCK family of proteins.[1] This domain functions as a guanine nucleotide exchange factor (GEF) domain for small G proteins of the Rho family.[2] DHR2 domains bear no significant similarity to the well described DH domain (Dbl homologous domain) present in other RhoGEFs such as Vav, P-Rex and TRIO. Indeed, the most divergent mammalian DHR2 domains share only 16-17% sequence similarity. References1. ^{{cite journal | vauthors = Meller N, Merlot S, Guda C | title = CZH proteins: a new family of Rho-GEFs | journal = J. Cell Sci. | volume = 118 | issue = Pt 21 | pages = 4937–46 |date=November 2005 | pmid = 16254241 | doi = 10.1242/jcs.02671| url = | issn = }} 2. ^{{cite journal | vauthors = Côté JF, Vuori K | title = Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity | journal = J. Cell Sci. | volume = 115 | issue = Pt 24 | pages = 4901–13|date=December 2002 | pmid = 12432077 | doi = 10.1242/jcs.00219| url = | issn = }} Further reading{{refbegin | 2}}
1 : Protein domains |
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