- Classification
- Nomenclature
- Biological role
- References
| Name = diacylglycerol cholinephosphotransferase
| EC_number = 2.7.8.2
| CAS_number = 9026-13-5
| IUBMB_EC_number = 2/7/8/2
| GO_code = 0004142
| image =
| width =
| caption =
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In enzymology, a diacylglycerol cholinephosphotransferase ({{EC number|2.7.8.2}}) is an enzyme that catalyzes the chemical reaction
CDP-choline + 1,2-diacylglycerol 
CMP + a phosphatidylcholine
CMP + a phosphatidylcholineThus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.[1]
Classification
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.
Nomenclature
The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:
{{div col|colwidth=25em}}- 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
- 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase,
- 1-alkyl-2-acetylglycerol cholinephosphotransferase,
- alkylacylglycerol choline phosphotransferase,
- alkylacylglycerol cholinephosphotransferase,
- CDP-choline diglyceride phosphotransferase,
- cholinephosphotransferase,
- CPT,
- cytidine diphosphocholine glyceride transferase,
- cytidine diphosphorylcholine diglyceride transferase,
- diacylglycerol choline phosphotransferase,
- phosphocholine diacylglyceroltransferase,
- phosphorylcholine-glyceride transferase, and
- sn-1,2-diacylglycerol cholinephosphotransferase.
Biological role
This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.
References
1. ^{{cite journal | vauthors = Coleman R, Bell RM | date = 1977 | title = Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities | journal = J. Biol. Chem. | volume = 252 | pages = 3050–6 | pmid = 192727 | issue = 9 }}
- {{cite journal | vauthors = Lee TC, Blank ML, Fitzgerald V, Snyder F | date = 1982 | title = Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver | journal = Biochim. Biophys. Acta | volume = 713 | pages = 479–83 | pmid = 6295501 | issue = 2 | doi=10.1016/0005-2760(82)90269-7}}
- {{cite journal | vauthors = Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ | date = 1978 | title = Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate | journal = Lipids | volume = 13 | pages = 161–4 | pmid = 204847 | doi = 10.1007/BF02533260 | issue = 2 }}
- {{cite journal | vauthors = Renooij W, Snyder F | date = 1981 | title = Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues | journal = Biochim. Biophys. Acta | volume = 663 | pages = 545–56 | pmid = 6260215 | issue = 2 | doi=10.1016/0005-2760(81)90182-x}}
2 : EC 2.7.8|Enzymes of unknown structure
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