| 词条 | Dichlorotetrakis(dimethylsulfoxide)ruthenium(II) | ||||
| 释义 |
| verifiedrevid = 389104871 | Name = Dichlorotetrakis(dimethyl sulfoxide) ruthenium (II) | ImageFileL1 = RuCl2-dmso4.PNG | ImageSizeL1 = 150 px | ImageFileR1 = Cis-fac-dichlorotetrakis(dimethyl-sulfoxide)ruthenium(II)-from-xtal-2008-3D-balls.png | ImageSizeR1 = 150 px | ImageFile2 = RuCl2(dmso)4 (Strem).jpg | ImageSize2 = 300 px | SystematicName = Ruthenium, dichlorotetrakis(sulfinylbis(methane))- (9CI) | OtherNames = Tetrakis(dimethylsulfoxide)dichlororuthenium(II), Dichlorotetrakis(methylsulfoxide)ruthenium, Dichlorotetrakis(sulfinylbis(methane))ruthenium | Section1 = {{Chembox Identifiers | CASNo = 11070-19-2 | PubChem = 150194 | ChemSpiderID = 132402 | StdInChI=1S/4C2H6OS.2ClH.Ru/c4*1-4(2)3;;;/h4*1-2H3;2*1H;/q;;;;;;+2/p-2 | StdInChIKey = UMJDEUKQHKMAOI-UHFFFAOYSA-L | SMILES = CS(=O)C.CS(=O)C.CS(=O)C.CS(=O)C.Cl[Ru]Cl }} | Section2 = {{Chembox Properties | Formula = C8H24Cl2O4RuS4 | MolarMass = 484.51{{nbsp}}g/mol | Appearance = Various shades of yellow crystals | Solubility = Miscible in water | SolubleOther = Nitromethane, chloroform, dichloromethane }} | Section3 = {{Chembox Structure | Coordination = Octahedral coordinate }} }} Dichlorotetrakis(dimethyl sulfoxide) ruthenium(II) describes coordination compounds with the formula RuCl2(dmso)4, where DMSO is dimethylsulfoxide. Both cis and trans isomers are known, but the cis isomer is more common. The cis isomer (pictured) is a yellow, air-stable solid that is soluble in some organic solvents. These compounds have attracted attention as possible anti-cancer drugs. Structure and synthesisThe cis isomer illustrates linkage isomerism for the DMSO ligand.[1] Three dmso ligands are S-bonded and one that is cis to both chloride ligands is O-bonded. In the trans isomer, which is also yellow, all four dmso ligands are S-bonded. The cis isomer is formed by thermally, and the trans isomer is obtained by UV-irradiation of the cis isomer.[2] The complexes were first prepared by heating DMSO solutions of ruthenium trichloride under hydrogen atmosphere.[2] An alternative procedure has been developed which avoids hydrogen gas.[3][4] Potential applicationsRuCl2(dmso)4 was identified as a potential anticancer agent in the early 1980s.[5] Continued research[6][7] has led to the development of several related dmso-containing ruthenium compounds, some of which have undergone early-stage clinical trials.[8] References1. ^{{cite journal | author = Enzo Alessio | title = Synthesis and reactivity of Ru-, Os-, Rh-, and Ir-halide-sulfoxide compounds | journal = Chem. Rev. | year = 2004 | volume = 104 | pages = 4203–4242 | doi = 10.1021/cr0307291 | issue = 9}} {{Ruthenium compounds}}2. ^{{cite journal |author1=B. R. James |author2=E. Ochiai |author3=G.I. Rempel | journal = Inorganic and Nuclear Chemistry Letters| volume = 7 | pages = 781–784 | year = 1971 | doi = 10.1016/0020-1650(71)80091-0 | title = Ruthenium (II) halide dimethylsulphoxide complexes from hydrogenation reactions | issue = 8}} 3. ^1 {{cite journal |author1=I. Bratsos |author2=E. Alessio | journal = Inorganic Syntheses | volume = 35 | pages = 148–152 | year = 2010 | title = Ruthenium(II) Chloro Complexes of dimethylsulfoxide | doi = 10.1002/9780470651568.ch8 }} 4. ^{{cite journal |author1=Nagy, E. M. |author2=Pettenuzzo, A. | journal = A European Journal | volume = 18 | pages = 14464–14472 | year = 2012 | title = Ruthenium(II/III)-Based Compounds with Encouraging Antiproliferative Activity against Non-small-Cell Lung Cancer | doi=10.1002/chem.201202171}} 5. ^{{cite journal|last1=Sava|first1=Gianni|last2=Giraldi|first2=Tullio|last3=Mestroni|first3=Giovanni|last4=Zassinovich|first4=Grazia|title=Antitumor effects of rhodium(I), iridium(I) and ruthenium(II) complexes in comparison with cis-dichlorodiammino platinum(II) in mice bearing Lewis lung carcinoma|journal=Chemico-Biological Interactions|date=July 1983|volume=45|issue=1|pages=1–6|doi=10.1016/0009-2797(83)90037-6}} 6. ^{{cite journal|last1=Coluccia|first1=Mauro|last2=Sava|first2=Gianni|last3=Loseto|first3=Francesco|last4=Nassi|first4=Anna|last5=Boccarelli|first5=Angela|last6=Giordano|first6=Domenico|last7=Alessio|first7=Enzo|last8=Mestroni|first8=Giovanni|title=Anti-leukaemic action of RuCl2(DMSO)4 isomers and prevention of brain involvement on P388 leukaemia and on subline|journal=European Journal of Cancer|date=January 1993|volume=29|issue=13|pages=1873–1879|doi=10.1016/0959-8049(93)90541-M}} 7. ^{{cite journal |author1=Bratsos, I |author2=Serli, B |author3=Zangranko, E |author4=Katsaros, N |author5=Alessio, E. | title = Replacement of chlorides with dicarboxylate ligands in anticancer active Ru(II)-DMSO compounds: A new strategy that might lead to improved activity | journal = Inorg. Chem. | volume = 46 | pages = 975–992 | doi = 10.1021/ic0613964 | year = 2007 | pmid=17257042 | issue = 3}} 8. ^{{cite journal|last1=Enzo Alessio|first1=Bentham Science Publisher|last2=Giovanni Mestroni|first2=Bentham Science Publisher|last3=Alberta Bergamo|first3=Bentham Science Publisher|last4=Gianni Sava|first4=Bentham Science Publisher|title=Ruthenium Antimetastatic Agents|journal=Current Topics in Medicinal Chemistry|date=1 November 2004|volume=4|issue=15|pages=1525–1535|doi=10.2174/1568026043387421}} 3 : Coordination compounds|Ruthenium complexes|Chloro complexes |
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