| 词条 | Diffuse alveolar damage |
| 释义 |
| name = {{PAGENAME}} | synonyms = | image = Hyaline membranes - very high mag.jpg | alt = | caption = Micrograph showing hyaline membranes, the key histologic feature of diffuse alveolar damage. H&E stain. | pronounce = | field = Repirology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} Diffuse alveolar damage is a histological pattern in lung disease. It is seen in acute respiratory distress syndrome (ARDS),[1] transfusion related acute lung injury (TRALI) and acute interstitial pneumonia (AIP). CauseDiffuse alveolar damage is associated primarily with ARDS and TRALI in adults, and hyaline membrane disease in neonates. It is most commonly associated with infection.[2] Diagnosis{{Empty section|date=June 2018}}Diagnosis of ARDS is based on clinical manifestation and its severity is evaluated with ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FIO2).[3] PrevalenceIt is a common biopsy finding.[4] Through histology, diffuse alveolar damage goes through several stages:
References1. ^{{cite book |author=Cotran, Ramzi S. |author2=Kumar, Vinay |author3=Fausto, Nelson |author4=Nelso Fausto |author5=Robbins, Stanley L. |author6=Abbas, Abul K. |title=Robbins and Cotran pathologic basis of disease |publisher=Elsevier Saunders |location=St. Louis, Mo |year=2005 |pages=715 |isbn=978-0-7216-0187-8 |oclc= |doi= |accessdate=}} 2. ^{{cite journal |vauthors=Parambil JG, Myers JL, Aubry MC, Ryu JH |title=Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy |journal=Chest |volume=132 |issue=1 |pages=50–7 |date=July 2007 |pmid=17475632 |doi=10.1378/chest.07-0104 }} 3. ^{{cite journal |title=Acute Respiratory Distress Syndrome |journal=JAMA |date=20 June 2012 |volume=307 |issue=23 |pages=2526–33 |doi=10.1001/jama.2012.5669 |pmid=22797452 |pmc=3408735 |author1=ARDS Definition Task Force |last2=Ranieri |first2=V. M. |last3=Rubenfeld |first3=G. D. |last4=Thompson |first4=B. T. |last5=Ferguson |first5=N. D. |last6=Caldwell |first6=E. |last7=Fan |first7=E. |last8=Camporota |first8=L. |last9=Slutsky |first9=A. S. }} 4. ^{{cite journal |vauthors=Parambil JG, Myers JL, Ryu JH |title=Diffuse alveolar damage: uncommon manifestation of pulmonary involvement in patients with connective tissue diseases |journal=Chest |volume=130 |issue=2 |pages=553–8 |date=August 2006 |pmid=16899858 |doi=10.1378/chest.130.2.553 }} External links{{Medical resources| ICD10 = | ICD9 = | ICDO = | OMIM = | DiseasesDB = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeSH = | GeneReviewsNBK = | GeneReviewsName = | Orphanet = }}
1 : Histopathology |
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