| 词条 | Dimethylaminopropylamine |
| 释义 |
| IUPACName = | SystematicName = N,N-Dimethyl-1,3-diaminopropane | PIN = N1,N1-dimethylpropane-1,3-diamine | OtherNames = {{unbulleted list|3-(Dimethylamino)-1-propylamine | 3-Dimethylaminopropylamine | N,N-Dimethyl-1,3-propanediamine }} | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 396485022 | ImageFile = Dimethylaminopropylamine.png | ImageFile_Ref = {{chemboximage|correct|??}} | ImageSize = 160 | ImageName = Skeletal formula of dimethylaminopropylamine |Section1={{Chembox Identifiers | CASNo = 109-55-7 | CASNo_Ref = {{cascite|correct|CAS}} | PubChem = 7993 | ChemSpiderID = 7703 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | EINECS = 203-680-9 | UNNumber = 2733 | MeSHName = 3-dimethylaminopropylamine | ChEMBL = 1232234 | ChEMBL_Ref = {{ebicite|changed|EBI}} | RTECS = TX7525000 | SMILES = CN(C)CCCN | StdInChI = 1S/C5H14N2/c1-7(2)5-3-4-6/h3-6H2,1-2H3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = IUNMPGNGSSIWFP-UHFFFAOYSA-N | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |Section2={{Chembox Properties | C=5 | H=14 | N=2 | Appearance = Colourless liquid | Odor = Ichtyal, ammoniacal | Density = 812 mg mL−1 | BoilingPtK = 405.2 | LogP = −0.211 | VaporPressure = 0.7–2.4 kPa | RefractIndex = 1.435–1.436 |Section3={{Chembox Thermochemistry | DeltaHf = −76.9–−76.9 kJ mol−1 | DeltaHc = −3.8955–−3.8875 MJ mol−1 | Entropy = 323.0 J K−1 mol−1 | HeatCapacity = 255.7 J K−1 mol−1 |Section4={{Chembox Hazards | GHSPictograms = {{gHS flame}} {{gHS corrosion}} {{gHS exclamation mark}} | GHSSignalWord = DANGER | HPhrases = {{h-phrases|226|302|314|317}} | PPhrases = {{p-phrases|280|305+351+338|310}} | FlashPtC = 32 | ExploLimits = 2.3–12.36% | LD50 = {{unbulleted list|487 mg kg−1 (dermal, rabbit)|1.87 g kg−1 (oral, rat)}} |Section5={{Chembox Related | OtherFunction_label = amines | OtherFunction = {{unbulleted list|Dimethylamine|Trimethylamine|N-Nitrosodimethylamine|Diethylamine|Triethylamine|Diisopropylamine|Diethylenetriamine|N,N-Diisopropylethylamine|Triisopropylamine|Tris(2-aminoethyl)amine|Mechlorethamine|HN1 (nitrogen mustard)|HN3 (nitrogen mustard)}} | OtherCompounds = {{unbulleted list|Unsymmetrical dimethylhydrazine|Biguanide|Dithiobiuret|Agmatine}} }} Dimethylaminopropylamine (aka "DMAPA") is a diamine used in the preparation of some surfactants, such as cocamidopropyl betaine which is an ingredient in many personal care products including soaps, shampoos, and cosmetics. DMAPA is commonly produced commercially via the reaction between dimethylamine and acrylonitrile (a Michael reaction) to produce dimethylaminopropionitrile. A subsequent hydrogenation step yields DMAPA. Health effectsDimethylaminopropylamine is a known skin irritant and its presence as an impurity in cocamidopropyl betaine is thought to be the cause of irritation experienced by some individuals.[1][2] See also
References1. ^{{cite journal|last1=Angelini|first1=Gianni|last2=Foti|first2=Caterina|last3=Rigano|first3=Luigi|last4=Vena|first4=Gino A.|title=3-Dimethylaminopropylamine: a key substance in contact allergy to cocamidopropylbetaine?|journal=Contact Dermatitis|date=February 1995|volume=32|issue=2|pages=96–99|doi=10.1111/j.1600-0536.1995.tb00754.x}} 2. ^{{cite journal|last1=PIGATTO|first1=P|title=Contact dermatitis to cocamidopropylbetaine is caused by residual amines: Relevance, clinical characteristics, and review of the literature|journal=American Journal of Contact Dermatitis|date=March 1995|volume=6|issue=1|pages=13–16|doi=10.1016/1046-199X(95)90062-4}} 1 : Diamines |
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