词条 | Disulfide bond formation protein B |
释义 |
| Symbol = DsbB | Name = | image =2hi7.png | width =250 | caption =Disulfide bond formation protein B (red), complex with DsbA (blue) | Pfam= PF02600 | InterPro= IPR003752 | SMART= | PROSITE = | SCOP = | TCDB = 5.A.2 | OPM family=173 | OPM protein=2hi7 | PDB= }} Disulfide bond formation protein B (DsbB) is a protein component of the pathway that leads to disulfide bond formation in periplasmic proteins of Escherichia coli and other bacteria. The DsbB protein oxidizes the periplasmic protein DsbA which in turn oxidizes cysteines in other periplasmic proteins in order to make disulfide bonds.[1] DsbB acts as a redox potential transducer across the cytoplasmic membrane. It is a membrane protein which spans the membrane four times with both the N- and C-termini of the protein are in the cytoplasm. Each of the periplasmic domains of the protein has two essential cysteines. The two cysteines in the first periplasmic domain are in a Cys-X-Y-Cys configuration that is characteristic of the active site of other proteins involved in disulfide bond formation, including DsbA and protein disulfide isomerase.[2] See also
References1. ^{{cite journal |vauthors=Lee JO, Beckwith J, Bardwell JC, Jander G, Martin N, Belin D |title=A pathway for disulfide bond formation in vivo |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue=3 |pages=1038–1042 |year=1993 |pmid=8430071 |doi=10.1073/pnas.90.3.1038 |pmc=45806}} {{InterPro content|IPR003752}}{{DEFAULTSORT:Disulfide Bond Formation Protein B}}{{membrane-protein-stub}}2. ^{{cite journal |vauthors=Beckwith J, Jander G, Martin NL |title=Two cysteines in each periplasmic domain of the membrane protein DsbB are required for its function in protein disulfide bond formation |journal=EMBO J. |volume=13 |issue=21 |pages=5121–5127 |year=1994 |pmid=7957076 |pmc=395459}} 3 : Protein domains|Protein families|Transmembrane proteins |
随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。