| 释义 |
- See Also
- References
- Further reading
{{Underlinked|date=May 2016}}{{Infobox_gene}}Dickkopf-related protein 2 is a protein that in humans is encoded by the DKK2 gene.[1][2]This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).[2] See Also- Hairy palms and soles [3]
References1. ^{{cite journal | vauthors = Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA | title = Functional and structural diversity of the human Dickkopf gene family | journal = Gene | volume = 238 | issue = 2 | pages = 301–13 |date=Dec 1999 | pmid = 10570958 | pmc = | doi =10.1016/S0378-1119(99)00365-0 }}
2. ^1 {{cite web | title = Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27123| accessdate = }}
3. ^{{cite journal |last1=Song |first1=Yaolin |last2=Boncompagni |first2=Ana C. |last3=Kim |first3=Sang-Seok |last4=Gochnauer |first4=Heather R. |last5=Zhang |first5=Yuhang |last6=Loots |first6=Gabriela G. |last7=Wu |first7=Dianqing |last8=Li |first8=Yulin |last9=Xu |first9=Mingang |last10=Millar |first10=Sarah E. |title=Regional Control of Hairless versus Hair-Bearing Skin by Dkk2 |journal=Cell Reports |date=December 2018 |volume=25 |issue=11 |pages=2981–2991.e3 |doi=10.1016/j.celrep.2018.11.017}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Wu W, Glinka A, Delius H, Niehrs C |title=Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling. |journal=Curr. Biol. |volume=10 |issue= 24 |pages= 1611–4 |year= 2001 |pmid= 11137016 |doi=10.1016/S0960-9822(00)00868-X }}
- {{cite journal | vauthors=Mao B, Wu W, Li Y |title=LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. |journal=Nature |volume=411 |issue= 6835 |pages= 321–5 |year= 2001 |pmid= 11357136 |doi= 10.1038/35077108 |display-authors=etal}}
- {{cite journal | vauthors=Li L, Mao J, Sun L |title=Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 5977–81 |year= 2002 |pmid= 11742004 |doi= 10.1074/jbc.M111131200 |display-authors=etal}}
- {{cite journal | vauthors=Brott BK, Sokol SY |title=Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6100–10 |year= 2002 |pmid= 12167704 |doi=10.1128/MCB.22.17.6100-6110.2002 | pmc=133995 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Mao B, Niehrs C |title=Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. |journal=Gene |volume=302 |issue= 1–2 |pages= 179–83 |year= 2003 |pmid= 12527209 |doi=10.1016/S0378-1119(02)01106-X }}
- {{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Kuphal S, Lodermeyer S, Bataille F |title=Expression of Dickkopf genes is strongly reduced in malignant melanoma. |journal=Oncogene |volume=25 |issue= 36 |pages= 5027–36 |year= 2006 |pmid= 16568085 |doi= 10.1038/sj.onc.1209508 |display-authors=etal}}
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