“DLGAP4”的意思、由来-开放百科全书

Function

DAP-4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. DAP-4 can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[2]

References

1. ^{{cite journal |vauthors=Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y | title = SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density | journal = J Biol Chem | volume = 272 | issue = 18 | pages = 11943–51 |date=Jun 1997 | pmid = 9115257 | pmc = | doi =10.1074/jbc.272.18.11943 }}
2. ^¹{{cite web | title = Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22839| accessdate = }}

Further reading

{{cite journal |vauthors=Kim JH, Liao D, Lau LF, Huganir RL |title=SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family |journal=Neuron |volume=20 |issue= 4 |pages= 683–91 |year= 1998 |pmid= 9581761 |doi=10.1016/S0896-6273(00)81008-9 }}

{{cite journal |vauthors=Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB |title=A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II |journal=Neuron |volume=20 |issue= 5 |pages= 895–904 |year= 1998 |pmid= 9620694 |doi=10.1016/S0896-6273(00)80471-7 }}

{{cite journal | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=10.1093/dnares/6.1.63 |name-list-format=vanc| author2=Ishikawa K | author3=Suyama M | display-authors=3 | last4=Kikuno | first4=R | last5=Hirosawa | first5=M | last6=Miyajima | first6=N | last7=Tanaka | first7=A | last8=Kotani | first8=H | last9=Nomura | first9=N }}

{{cite journal | author=Kawabe H |title=nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30914–8 |year= 1999 |pmid= 10521485 |doi=10.1074/jbc.274.43.30914 |name-list-format=vanc| author2=Hata Y | author3=Takeuchi M | display-authors=3 | last4=Ide | first4=N | last5=Mizoguchi | first5=A | last6=Takai | first6=Y }}

{{cite journal | author=Husi H |title=Proteomic analysis of NMDA receptor-adhesion protein signaling complexes |journal=Nat. Neurosci. |volume=3 |issue= 7 |pages= 661–9 |year= 2000 |pmid= 10862698 |doi= 10.1038/76615 |name-list-format=vanc| author2=Ward MA | author3=Choudhary JS | display-authors=3 | last4=Choudhary | first4=Jyoti S. | last5=Blackstock | first5=Walter P. }}

{{cite journal |vauthors=Pei L, Teves RL, Wallace MC, Gurd JW |title=Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP |journal=J. Cereb. Blood Flow Metab. |volume=21 |issue= 8 |pages= 955–63 |year= 2001 |pmid= 11487731 |doi= 10.1097/00004647-200108000-00008 }}

{{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |name-list-format=vanc| author2=Matthews LH | author3=Ashurst J | display-authors=3 | last4=Burton | first4=J. | last5=Gilbert | first5=J. G. R. | last6=Jones | first6=M. | last7=Stavrides | first7=G. | last8=Almeida | first8=J. P. | last9=Babbage | first9=A. K. }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Riefler GM |title=Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor) |journal=Biochem. J. |volume=373 |issue= Pt 1 |pages= 49–55 |year= 2003 |pmid= 12675619 |doi= 10.1042/BJ20021838 | pmc=1223477 |name-list-format=vanc| author2=Balasingam G | author3=Lucas KG | display-authors=3 | last4=Wang | first4=Sheng | last5=Hsu | first5=Shu-Chan | last6=Firestein | first6=Bonnie L. }}

{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}

{{cite journal |vauthors=Song B, Yan XB, Zhang GY |title=PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus |journal=Brain Res. |volume=1005 |issue= 1–2 |pages= 44–50 |year= 2004 |pmid= 15044063 |doi= 10.1016/j.brainres.2004.01.032 }}

{{cite journal | author=Brandenberger R |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |name-list-format=vanc| author2=Wei H | author3=Zhang S | display-authors=3 | last4=Lei | first4=Shirley | last5=Murage | first5=Jaji | last6=Fisk | first6=Gregory J | last7=Li | first7=Yan | last8=Xu | first8=Chunhui | last9=Fang | first9=Rixun }}

{{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-format=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}