请输入您要查询的百科知识:

 

词条 DNA damage-inducible transcript 3
释义

  1. Interactions

  2. Clinical significance

  3. References

  4. Further reading

  5. External links

{{Infobox_gene}}DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene.[1][2]

Interactions

DNA damage-inducible transcript 3 has been shown to interact with [proteins]:

{{div col|colwidth=20em}}
  • ATF3,[3]
  • C-Fos,[4]
  • C-jun[4] and
  • CEBPB,[4][5]
  • CSNK2A1,[6]
  • JunD,[7] and
  • RPS3A.[8]
{{Div col end}}

Clinical significance

During endoplasmic reticulum stress (such as occurs in beta cells of the pancreas or in macrophages causing atherosclerosis), CHOP can induce activation of Ero1, causing calcium release from the endoplasmic reticulum into the cytoplasm, resulting in apoptosis.[9] CHOP also induces apoptosis during endoplasmic reticulum stress by activating growth arrest and DNA damage-inducible protein GADD34.[10]

Mutations or fusions of CHOP (e.g. with FUS to form FUS-CHOP) can cause Myxoid liposarcoma.[11]

References

1. ^{{cite journal | vauthors = Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, ((Alamo I Jr)), Barrett SF, Hickson ID, ((Fornace AJ Jr)) | title = Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C | journal = Mol Cell Biol | volume = 11 | issue = 2 | pages = 1009–16 |date=March 1991 | pmid = 1990262 | pmc = 359769 | doi = }}
2. ^{{cite web | title = Entrez Gene: DDIT3 DNA-damage-inducible transcript 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1649| accessdate = }}
3. ^{{cite journal | date = March 1996 | vauthors = Chen BP, Wolfgang CD, Hai T | title = Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10 | journal = Mol. Cell. Biol. | volume = 16 | issue = 3 | pages = 1157–68 | pmid = 8622660 | pmc = 231098 | doi = 10.1128/MCB.16.3.1157}}
4. ^{{cite journal | date = April 2003 | vauthors = Hattori T, Ohoka N, Hayashi H, Onozaki K | title = C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform | journal = FEBS Lett. | volume = 541 | issue = 1-3 | pages = 33–9 | pmid = 12706815 | doi = 10.1016/s0014-5793(03)00283-7}}
5. ^{{cite journal | date = June 1996 | vauthors = Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ | title = Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress | journal = J. Biol. Chem. | volume = 271 | issue = 24 | pages = 14285–9 | pmid = 8662954 | doi = 10.1074/jbc.271.24.14285}}
6. ^{{cite journal | date = October 2003 | vauthors = Ubeda M, Habener JF | title = CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation | journal = J. Biol. Chem. | volume = 278 | issue = 42 | pages = 40514–20 | pmid = 12876286 | doi = 10.1074/jbc.M306404200}}
7. ^{{cite journal | date = November 1999 | vauthors = Ubeda M, Vallejo M, Habener JF | title = CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins | journal = Mol. Cell. Biol. | volume = 19 | issue = 11 | pages = 7589–99 | pmid = 10523647 | pmc = 84780 | doi = }}
8. ^{{cite journal | date = March 2000 | vauthors = Cui K, Coutts M, Stahl J, Sytkowski AJ | title = Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis | journal = J. Biol. Chem. | volume = 275 | issue = 11 | pages = 7591–6 | pmid = 10713066 | doi = 10.1074/jbc.275.11.7591}}
9. ^{{cite journal | vauthors=Li G, Mongillo M, Chin KT, Harding H, Ron D, Marks AR, Tabas I | title=Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis | journal= Journal of Cell Biology | volume=186 | issue=6 | pages=783-792 | year=2009 | doi=10.1083/jcb.200904060 | pmid = 19752026 | pmc=2753154 }}
10. ^{{cite journal | vauthors=Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D | title=CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum | journal= Genes & Development | volume=18 | issue=24 | pages=3066-3077 | year=2004 | doi=10.1101/gad.1250704| pmid = 15601821 | pmc=535917 }}
11. ^{{cite journal | author=Panagopoulos I |title=Fusion of the EWS and CHOP genes in myxoid liposarcoma |journal=Oncogene |volume=12 |issue= 3 |pages= 489–94 |year= 1996 |pmid= 8637704 |doi= |name-list-format=vanc| author2=Höglund M | author3=Mertens F | display-authors=3 | last4=Mandahl | first4=N | last5=Mitelman | first5=F | last6=Aman | first6=P }}

Further reading

{{refbegin|35em}}
  • {{cite journal | vauthors=Ramji DP, Foka P |title=CCAAT/enhancer-binding proteins: structure, function and regulation |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 561–75 |year= 2002 |pmid= 12006103 |doi= 10.1042/BJ20020508 | pmc=1222736 }}
  • {{cite journal | vauthors=Oyadomari S, Mori M |title=Roles of CHOP/GADD153 in endoplasmic reticulum stress |journal=Cell Death Differ. |volume=11 |issue= 4 |pages= 381–9 |year= 2004 |pmid= 14685163 |doi= 10.1038/sj.cdd.4401373 }}
  • {{cite journal | author=Aman P |title=Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11) |journal=Genes Chromosomes Cancer |volume=5 |issue= 4 |pages= 278–85 |year= 1993 |pmid= 1283316 |doi=10.1002/gcc.2870050403 |name-list-format=vanc| author2=Ron D | author3=Mandahl N | display-authors=3 | last4=Fioretos | first4=Thoas | last5=Heim | first5=Sverre | last6=Arheden | first6=Kristina | last7=Willén | first7=Helena | last8=Rydholm | first8=Anders | last9=Mitelman | first9=Felix }}
  • {{cite journal | author=Park JS |title=Isolation, characterization and chromosomal localization of the human GADD153 gene |journal=Gene |volume=116 |issue= 2 |pages= 259–67 |year= 1992 |pmid= 1339368 |doi=10.1016/0378-1119(92)90523-R |name-list-format=vanc| author2=Luethy JD | author3=Wang MG | display-authors=3 | last4=Fargnoli | first4=Joseph | last5=Fornace | first5=Albert J | last6=Wesley Mcbride | first6=O | last7=Holbrook | first7=Nikki J }}
  • {{cite journal | vauthors=Ron D, Habener JF |title=CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription |journal=Genes Dev. |volume=6 |issue= 3 |pages= 439–53 |year= 1992 |pmid= 1547942 |doi=10.1101/gad.6.3.439 }}
  • {{cite journal | author=Eneroth M |title=Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2 |journal=Cancer Genet. Cytogenet. |volume=48 |issue= 1 |pages= 101–7 |year= 1990 |pmid= 2372777 |doi=10.1016/0165-4608(90)90222-V |name-list-format=vanc| author2=Mandahl N | author3=Heim S | display-authors=3 | last4=Willen | first4=H | last5=Rydholm | first5=A | last6=Alberts | first6=K | last7=Mitelman | first7=F }}
  • {{cite journal | vauthors=Rabbitts TH, Forster A, Larson R, Nathan P |title=Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma |journal=Nat. Genet. |volume=4 |issue= 2 |pages= 175–80 |year= 1993 |pmid= 7503811 |doi= 10.1038/ng0693-175 }}
  • {{cite journal | vauthors=Crozat A, Aman P, Mandahl N, Ron D |title=Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma |journal=Nature |volume=363 |issue= 6430 |pages= 640–4 |year= 1993 |pmid= 8510758 |doi= 10.1038/363640a0 }}
  • {{cite journal | vauthors=Chen BP, Wolfgang CD, Hai T |title=Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10 |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1157–68 |year= 1996 |pmid= 8622660 |doi= 10.1128/MCB.16.3.1157| pmc=231098 }}
  • {{cite journal | vauthors=Wang XZ, Ron D |title=Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase |journal=Science |volume=272 |issue= 5266 |pages= 1347–9 |year= 1996 |pmid= 8650547 |doi=10.1126/science.272.5266.1347 }}
  • {{cite journal | vauthors=Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ |title=Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14285–9 |year= 1996 |pmid= 8662954 |doi=10.1074/jbc.271.24.14285 }}
  • {{cite journal | vauthors=Ubeda M, Vallejo M, Habener JF |title=CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7589–99 |year= 1999 |pmid= 10523647 |doi= | pmc=84780 }}
  • {{cite journal | vauthors=Cui K, Coutts M, Stahl J, Sytkowski AJ |title=Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7591–6 |year= 2000 |pmid= 10713066 |doi=10.1074/jbc.275.11.7591 }}
  • {{cite journal | vauthors=Gotoh T, Oyadomari S, Mori K, Mori M |title=Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12343–50 |year= 2002 |pmid= 11805088 |doi= 10.1074/jbc.M107988200 }}
  • {{cite journal | author=Satoh T |title=Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells |journal=Oncogene |volume=21 |issue= 14 |pages= 2171–80 |year= 2002 |pmid= 11948400 |doi= 10.1038/sj.onc.1205279 |name-list-format=vanc| author2=Toyoda M | author3=Hoshino H | display-authors=3 | last4=Monden | first4=Tsuyoshi | last5=Yamada | first5=Masanabu | last6=Shimizu | first6=Hiroyuki | last7=Miyamoto | first7=Kaoru | last8=Mori | first8=Matsumoto }}
  • {{cite journal | vauthors=Qiao D, Im E, Qi W, Martinez JD |title=Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis |journal=Biochim. Biophys. Acta |volume=1583 |issue= 1 |pages= 108–16 |year= 2002 |pmid= 12069855 |doi= 10.1016/s1388-1981(02)00190-7}}
  • {{cite journal | vauthors=Talukder AH, Wang RA, Kumar R |title=Expression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cells |journal=Oncogene |volume=21 |issue= 27 |pages= 4289–300 |year= 2002 |pmid= 12082616 |doi= 10.1038/sj.onc.1205529 }}
{{refend}}

External links

  • {{MeshName|DDIT3+protein,+human}}
{{NLM content}}{{Transcription factors|g1}}

2 : Transcription factors|Oncogenes

随便看

 

开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。

 

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间:2024/9/22 13:45:20