“DNMT3L”的意思、由来-开放百科全书

Function

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.^[2]

References

1. ^{{cite journal |vauthors=Aapola U, Kawasaki K, Scott HS, Ollila J, Vihinen M, Heino M, Shintani A, Kawasaki K, Minoshima S, Krohn K, Antonarakis SE, Shimizu N, Kudoh J, Peterson P | title = Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family | journal = Genomics | volume = 65 | issue = 3 | pages = 293–8 | date=August 2000| pmid = 10857753 | pmc = | doi = 10.1006/geno.2000.6168 }}
2. ^¹{{cite web | title = Entrez Gene: DNMT3L DNA (cytosine-5-)-methyltransferase 3-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29947| accessdate = }}
3. ^{{cite journal |vauthors=Aapola U, Liiv I, Peterson P | title = Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity | journal = Nucleic Acids Res. | volume = 30 | issue = 16 | pages = 3602–8 | year = 2002 | pmid = 12177302 | pmc = 134241 | doi = 10.1093/nar/gkf474 }}
4. ^{{cite journal |vauthors=Deplus R, Brenner C, Burgers WA, Putmans P, Kouzarides T, de Launoit Y, Fuks F | title = Dnmt3L is a transcriptional repressor that recruits histone deacetylase | journal = Nucleic Acids Res. | volume = 30 | issue = 17 | pages = 3831–8 |date=September 2002 | pmid = 12202768 | pmc = 137431 | doi = 10.1093/nar/gkf509 }}

Further reading

{{cite journal | author=Hattori M |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 |name-list-format=vanc| author2=Fujiyama A | author3=Taylor TD | display-authors=3 | last4=Taylor | first4=T. D. | last5=Watanabe | first5=H. | last6=Yada | first6=T. | last7=Park | first7=H.-S. | last8=Toyoda | first8=A. | last9=Ishii | first9=K. }}

{{cite journal |vauthors=Hata K, Okano M, Lei H, Li E |title=Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice |journal=Development |volume=129 |issue= 8 |pages= 1983–93 |year= 2002 |pmid= 11934864 |doi= }}

{{cite journal |vauthors=Burgers WA, Fuks F, Kouzarides T |title=DNA methyltransferases get connected to chromatin |journal=Trends Genet. |volume=18 |issue= 6 |pages= 275–7 |year= 2002 |pmid= 12044346 |doi=10.1016/S0168-9525(02)02667-7 }}

{{cite journal |vauthors=Aapola U, Liiv I, Peterson P |title=Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity |journal=Nucleic Acids Res. |volume=30 |issue= 16 |pages= 3602–8 |year= 2002 |pmid= 12177302 |doi=10.1093/nar/gkf474 | pmc=134241 }}

{{cite journal | author=Deplus R |title=Dnmt3L is a transcriptional repressor that recruits histone deacetylase |journal=Nucleic Acids Res. |volume=30 |issue= 17 |pages= 3831–8 |year= 2002 |pmid= 12202768 |doi=10.1093/nar/gkf509 | pmc=137431 |name-list-format=vanc| author2=Brenner C | author3=Burgers WA | display-authors=3 | last4=Putmans | first4=P | last5=Kouzarides | first5=T | last6=De Launoit | first6=Y | last7=Fuks | first7=F }}

{{cite journal | author=Kierszenbaum AL |title=Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking paths |journal=Mol. Reprod. Dev. |volume=63 |issue= 3 |pages= 269–72 |year= 2003 |pmid= 12237941 |doi= 10.1002/mrd.90011 }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal |vauthors=Chedin F, Lieber MR, Hsieh CL |title=The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16916–21 |year= 2003 |pmid= 12481029 |doi= 10.1073/pnas.262443999 | pmc=139244 }}

{{cite journal | author=Huntriss J |title=Expression of mRNAs for DNA methyltransferases and methyl-CpG-binding proteins in the human female germ line, preimplantation embryos, and embryonic stem cells |journal=Mol. Reprod. Dev. |volume=67 |issue= 3 |pages= 323–36 |year= 2004 |pmid= 14735494 |doi= 10.1002/mrd.20030 |name-list-format=vanc| author2=Hinkins M | author3=Oliver B | display-authors=3 | last4=Harris | first4=S.E. | last5=Beazley | first5=J.C. | last6=Rutherford | first6=A.J. | last7=Gosden | first7=R.G. | last8=Lanzendorf | first8=S.E. | last9=Picton | first9=H.M. }}

{{cite journal | author=Suetake I |title=DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 27816–23 |year= 2004 |pmid= 15105426 |doi= 10.1074/jbc.M400181200 |name-list-format=vanc| author2=Shinozaki F | author3=Miyagawa J | display-authors=3 | last4=Takeshima | first4=H | last5=Tajima | first5=S }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }}

{{cite journal | author=Hata K |title=Meiotic and epigenetic aberrations in Dnmt3L-deficient male germ cells |journal=Mol. Reprod. Dev. |volume=73 |issue= 1 |pages= 116–22 |year= 2006 |pmid= 16211598 |doi= 10.1002/mrd.20387 |name-list-format=vanc| author2=Kusumi M | author3=Yokomine T | display-authors=3 | last4=Li | first4=En | last5=Sasaki | first5=Hiroyuki }}

{{cite journal | author=Xie ZH |title=Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L |journal=Hum. Mol. Genet. |volume=15 |issue= 9 |pages= 1375–85 |year= 2006 |pmid= 16543361 |doi= 10.1093/hmg/ddl059 |name-list-format=vanc| author2=Huang YN | author3=Chen ZX | display-authors=3 | last4=Riggs | first4=AD | last5=Ding | first5=JP | last6=Gowher | first6=H | last7=Jeltsch | first7=A | last8=Sasaki | first8=H | last9=Hata | first9=K }}

{{cite journal |vauthors=Yokomine T, Hata K, Tsudzuki M, Sasaki H |title=Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting |journal=Cytogenet. Genome Res. |volume=113 |issue= 1–4 |pages= 75–80 |year= 2006 |pmid= 16575165 |doi= 10.1159/000090817 }}

{{cite journal | author=Hu YH |title=Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins |journal=BMC Genomics |volume=7|pages= 155 |year= 2006 |pmid= 16780588 |doi= 10.1186/1471-2164-7-155 | pmc=1526728 |name-list-format=vanc| author2=Warnatz HJ | author3=Vanhecke D | display-authors=3 | last4=Wagner | first4=Florian | last5=Fiebitz | first5=Andrea | last6=Thamm | first6=Sabine | last7=Kahlem | first7=Pascal | last8=Lehrach | first8=Hans | last9=Yaspo | first9=Marie-Laure }}

{{cite journal | author=Kareta MS |title=Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L |journal=J. Biol. Chem. |volume=281 |issue= 36 |pages= 25893–902 |year= 2006 |pmid= 16829525 |doi= 10.1074/jbc.M603140200 |name-list-format=vanc| author2=Botello ZM | author3=Ennis JJ | display-authors=3 | last4=Chou | first4=C | last5=Chédin | first5=F }}

{{cite journal | author=Ooi SK |title=DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA |journal=Nature |volume=448 |issue= 7154 |pages= 714–7 |year= 2007 |pmid= 17687327 |doi= 10.1038/nature05987 | pmc=2650820 |name-list-format=vanc| author2=Qiu C | author3=Bernstein E | display-authors=3 | last4=Li | first4=Keqin | last5=Jia | first5=Da | last6=Yang | first6=Zhe | last7=Erdjument-Bromage | first7=Hediye | last8=Tempst | first8=Paul | last9=Lin | first9=Shau-Ping }}

{{cite journal | author=Jia D |title=Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation |journal=Nature |volume=449 |issue= 7159 |pages= 248–51 |year= 2007 |pmid= 17713477 |doi= 10.1038/nature06146 | pmc=2712830 |name-list-format=vanc| author2=Jurkowska RZ | author3=Zhang X | display-authors=3 | last4=Jeltsch | first4=Albert | last5=Cheng | first5=Xiaodong }}

Function

Interactions

References

Further reading