| 词条 | Doege–Potter syndrome |
| 释义 |
| name = Doege–Potter syndrome | image = PBB Protein IGF2 image.jpg | caption = The structure of IGF-2, responsible for the hypoglycemia associated with Doege–Potter syndrome | pronounce = | specialty = Oncology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Doege–Potter syndrome (DPS) is a paraneoplastic syndrome[1] in which hypoglycemia is associated with solitary fibrous tumors. The hypoglycemia is the result of the tumors producing insulin-like growth factor 2.[2] The syndrome was first described in 1930, by Karl Walter Doege (1867–1932), a German-American physician[3] and by Roy Pilling Potter (1879–1968), an American radiologist, working independently;[4] the full term Doege–Potter syndrome was infrequently used until the publication of a 2000 article[5] using the eponym.[6] DPS is rare (as of 1976, less than one hundred cases were described[7]), with a malignancy rate of 12–15%. Actual rates of hypoglycemia associated with a fibrous tumor are quite rare (a 1981 study of 360 solitary fibrous tumors of the lungs found that only 4% caused hypoglycemia[8]), and are linked to large tumors with high rates of mitosis.[9] Removal of the tumor will normally resolve the symptoms.[1][9] Tumors causing DPS tend to be quite large;[10] in one case a {{convert|3|kg|lb|abbr=on}}, {{convert|23|*|21|*|12|cm|in|abbr=on}} mass was removed, sufficiently large to cause a collapsed lung.[5] In X-rays, they appear as a single mass with visible, defined borders, appearing at the edges of the lungs or a fissure dividing the lobes of the lungs.[10] Similar hypoglycemic effects have been related to mesenchymal tumors.[6] References1. ^1 {{cite journal |vauthors=Balduyck B, Lauwers P, Govaert K, Hendriks J, De Maeseneer M, Van Schil P |title=Solitary fibrous tumor of the pleura with associated hypoglycemia: Doege–Potter syndrome: a case report |journal=J Thorac Oncol |volume=1 |issue=6 |pages=588–90 |date=July 2006 |pmid=17409923 |doi= 10.1097/01243894-200607000-00016|url=}} 2. ^{{cite journal |vauthors=Herrmann BL, Saller B, Kiess W |title=Primary malignant fibrous histiocytoma of the lung: IGF-II producing tumor induces fasting hypoglycemia |journal=Exp. Clin. Endocrinol. Diabetes |volume=108 |issue=8 |pages=515–18 |year=2000 |pmid=11149628 |doi= 10.1055/s-2000-11007|url=|display-authors=etal}} 3. ^{{cite journal | last = Doege | first = KW | title = Fibrosarcoma of the mediastinum | journal = Ann Surg | year = 1930 | volume = 92 | pages = 955–960 | pmid = 17866430 | issue = 5 | pmc = 1398259 }} 4. ^{{cite journal |vauthors=Roy M, Burns MV, Overly DJ, Curd BT |title=Solitary fibrous tumor of the pleura with hypoglycemia: the Doege–Potter syndrome |journal=J Ky Med Assoc |volume=90 |issue=11 |pages=557–60 |date=November 1992 |pmid=1474302 |doi= |url=}} 5. ^1 {{cite journal |vauthors=Chamberlain MH, Taggart DP |title=Solitary fibrous tumor associated with hypoglycemia: an example of the Doege–Potter syndrome |journal=J. Thorac. Cardiovasc. Surg. |volume=119 |issue=1 |pages=185–7 |date=January 2000 |pmid=10612786 |doi=10.1016/S0022-5223(00)70242-X |url=http://jtcs.ctsnetjournals.org/cgi/content/full/119/1/185 |deadurl=yes |archiveurl=https://archive.is/20130112150111/http://jtcs.ctsnetjournals.org/cgi/content/full/119/1/185 |archivedate=2013-01-12 |df= }} 6. ^1 {{cite book |author=Shields, TW |author2=LoCicero J |author3=Ponn RB |author4=Rusch VW |title=General thoracic surgery |publisher=Lippincott Williams & Wilkins |location=Hagerstwon, MD |year=2005 |pages= [https://books.google.com/books?id=fnXVdoas1–UC&pg=PA893 893]|isbn=0-7817-3889-X |oclc= |doi= |access-date=}} 7. ^{{cite journal |vauthors=Ellorhaoui M, Graf B |title=[Intrathoracal tumor with accompanying hypoglycemia] |language=German |journal=Z Gesamte Inn Med |volume=31 |issue=3 |pages=77–81 |date=February 1976 |pmid=785836 |doi= |url=}} 8. ^{{cite journal |vauthors=Briselli M, Mark EJ, Dickersin GR |title=Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature |journal=Cancer |volume=47 |issue=11 |pages=2678–89 |date=June 1981 |pmid=7260861 |doi= 10.1002/1097-0142(19810601)47:11<2678::AID-CNCR2820471126>3.0.CO;2-9|url=}} 9. ^1 {{cite journal |vauthors=Zafar H, Takimoto CH, Weiss G |title=Doege–Potter syndrome: hypoglycemia associated with malignant solitary fibrous tumor |journal=Med. Oncol. |volume=20 |issue=4 |pages=403–08 |year=2003 |pmid=14716039 |doi=10.1385/MO:20:4:403 |url=}} 10. ^1 {{cite book |author=Light, Richard J. |title=Pleural diseases |publisher=Lippincott Williams & Wilkins |location=Hagerstwon, MD |year=2007 |pages= [https://books.google.com/books?id=vHEpRHQXaKUC&pg=PA172 172–3] |isbn=0-7817-6957-4 |oclc= |doi= |access-date=}} External links{{Medical resources| DiseasesDB = | ICD10 = | ICD9 = | ICDO = | OMIM = | OMIM_mult = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | eMedicine_mult = | MeshID = }}{{Paraneoplastic syndromes}}{{Endocrine gland neoplasia}}{{DEFAULTSORT:Doege-Potter syndrome}} 1 : Paraneoplastic syndromes |
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