IL28 or IL-28 may refer to:

• Ilyushin Il-28, an early Cold War era Soviet bomber aircraft
• Interleukin 28, a cytokine for stimulating the growth of T cell lymphocytes

• 1957 Pacoima mid-air collision
• 1957 pandemic
• 1957 Paris summit
• 1957 Peruvian Primera División
• 1957 PGA Championship
• 1957 Philadelphia Eagles season
• 1957 Philippine general election
• 1957 Philippine House of Representatives elections
• 1957 Philippine presidential election
• 1957 Pittsburgh mayoral election
• 1957 Pittsburgh Steelers season
• 1957 Pro Bowl
• 1957 Purdue Boilermakers football team
• 1957 Queensland state election
• 1957 Rose Bowl
• 1957 Saint-Paul bus accident
• 1957 San Francisco 49ers season
• 1957 Sardinian regional election
• 1957 SCCA National Sports Car Championship
• 1957 Segunda División Peruana
• 1957 Senegalese Territorial Assembly election
• 1957 Sierra Leonean general election
• 1957 (song)
• 1957 Soviet Top League
• 1957 Speedway National League