| 词条 | Doxanthrine |
| 释义 |
| verifiedrevid = 449581815 | IUPAC_name = (6aS,12bR)-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline-2,3-diol | image = Doxanthrine_structure.png | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = | ATC_prefix = none | ATC_suffix = | PubChem = 15981509 | ChemSpiderID = 13112900 | C=16 | H=15 | N=1 | O=3 | molecular_weight = 269.295 g/mol | smiles = c1ccc2c(c1)CN[C@H]3[C@H]2c4cc(c(cc4OC3)O)O | StdInChI = 1S/C16H15NO3/c18-13-5-11-15(6-14(13)19)20-8-12-16(11)10-4-2-1-3-9(10)7-17-12/h1-6,12,16-19H,7-8H2/t12-,16-/m1/s1 | StdInChIKey = QDUNOUQOKOYLCH-MLGOLLRUSA-N }}Doxanthrine is a synthetic compound which is a potent and selective full agonist for the dopamine D1 receptor.[1][2] Doxanthrine has been shown to be orally active in producing contralateral rotation in the 6-hydroxy-dopamine rat model of Parkinson's disease.[3] References1. ^{{cite journal |vauthors=Cueva JP, Giorgioni G, Grubbs RA, Chemel BR, Watts VJ, Nichols DE |title=trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist |journal=Journal of Medicinal Chemistry |volume=49 |issue=23 |pages=6848–57 |date=November 2006 |pmid=17154515 |doi=10.1021/jm0604979 |url=}} {{Dopaminergics}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Przybyla JA, Cueva JP, Chemel BR, Hsu KJ, Riese DJ, McCorvy JD, Chester JA, Nichols DE, Watts VJ |title=Comparison of the enantiomers of (±)-doxanthrine, a high efficacy full dopamine D1 receptor agonist, and a reversal of enantioselectivity at D1 versus alpha2C adrenergic receptors |journal=European Neuropsychopharmacology |volume=19 |issue=2 |pages=138–46 |date=February 2009 |pmid=19028082 |doi=10.1016/j.euroneuro.2008.10.002 |url= |pmc=2636714}} 3. ^{{cite journal |vauthors=McCorvey JD, Watts VJ, Nichols DE |date=July 2012 |title= Comparison of the D1 dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease |journal=Psychopharmacology |publisher= |volume=222 |pages=81–87 |doi=10.1007/s00213-011-2625-5 |pmid=22222862 |issue=1}} 2 : Dopamine agonists|Catechols |
| 随便看 |
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。