| 词条 | Doxpicomine |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 451554858 | IUPAC_name = 1-(1,3-dioxan-5-yl)-N,N-dimethyl-1-pyridin-3-ylmethanamine | image = Doxpicomine.png | tradename = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 69494-04-8 | ATC_prefix = none | ATC_suffix = | PubChem = ? | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 9821373UA1 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D03900 | C=12 | H=18 | N=2 | O=2 | molecular_weight = 222.283 g/mol | smiles = CN(C)C(C1COCOC1)C2=CN=CC=C2 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 64983 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C12H18N2O2/c1-14(2)12(10-4-3-5-13-6-10)11-7-15-9-16-8-11/h3-6,11-12H,7-9H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = SMZVRZPJXBGNFT-UHFFFAOYSA-N }}Doxpicomine (Doxpicodin, Doxpizodine) is a mild opioid analgesic drug.[1] The drug acts as a mu-opioid receptor agonist.[2] It is of fairly low potency, with a 400 mg dose of doxpicomine approximately equivalent in pain-killing effect to 8 mg morphine or 100 mg pethidine.[3][4] It has been used as a lead compound to derive further analogues, although all compounds in this family are comparatively weak mu agonists.[5] References1. ^{{ cite patent | country = US | number = 3905987 | status = patent | title = m-Dioxane-5-Methylamine Analgesics | inventor = Booher, R. N.| assign1 = Eli Lilly| gdate = 09/16/1975}} {{Analgesics}}{{Opioidergics}}2. ^{{Cite journal| pmid = 6261137| year = 1981| last1 = Smits | first1 = S. E.| last2 = Nickander | first2 = R.| last3 = Booher | first3 = R. N.| last4 = Zimmerman | first4 = D. M.| last5 = Wong | first5 = D. T.| last6 = Hynes | first6 = M. D.| last7 = Pohland | first7 = A.| title = Preclinical pharmacology of doxpicodin, a new analgesic| volume = 34| pages = 75–81| journal = NIDA Research Monograph}} 3. ^{{Cite journal| doi = 10.1038/clpt.1981.109| pmid = 7014073| year = 1981| last1 = Wang | first1 = R. I.| last2 = Robinson | first2 = N.| title = Doxpicomine in postoperative pain| volume = 29| issue = 6| pages = 771–775| journal = Clinical Pharmacology and Therapeutics}} 4. ^{{Cite journal| pmid = 6341416| year = 1983| last1 = Wang | first1 = R. I.| last2 = Robinson | first2 = N.| title = Further efficacy evaluation of doxpicomine for postoperative pain| volume = 23| issue = 1| pages = 44–47| journal = Journal of Clinical Pharmacology | doi=10.1002/j.1552-4604.1983.tb02703.x}} 5. ^{{Cite journal| doi = 10.1002/ardp.19933260311| pmid = 8481096| year = 1993| last1 = Wünsch | first1 = B.| last2 = Bauschke | first2 = G.| title = Benzomorphan analogs with doxpicomine partial structure: Synthesis andpsychopharmacologic investigations of 5-aminomethyl- and 5-(alpha-aminobenzyl)- substituted 2,6-epoxy-3-benzoxocines|trans-title= Benzomorphan analogs with doxpicomine partial structure: synthesis and psychopharmacologic investigations of 5-aminomethyl- and 5-(alpha-aminobenzyl)- substituted 2,6-epoxy-3-benzoxocines| language = German | volume = 326| issue = 3| pages = 171–180| journal = Archiv der Pharmazie}} 5 : Amines|Synthetic opioids|Pyridines|Dioxanes|Mu-opioid agonists |
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