| 释义 |
- Interactive pathway map
- References
- Further reading
{{Infobox_gene}}Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.[1][2]Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.[2] Interactive pathway map {{FluoropyrimidineActivity WP1601|highlight=DPYS}}References1. ^{{cite journal | vauthors = Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M | title = A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution | journal = Gene | volume = 180 | issue = 1-2 | pages = 157–63 |date=Jan 1997 | pmid = 8973361 | pmc = | doi =10.1016/S0378-1119(96)00445-3 }}
2. ^1 {{cite web | title = Entrez Gene: DPYS dihydropyrimidinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1807| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Thomas HR, Ezzeldin HH, Guarcello V |title=Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism. |journal=Pharmacogenet. Genomics |volume=18 |issue= 1 |pages= 25–35 |year= 2008 |pmid= 18216719 |doi= 10.1097/FPC.0b013e3282f2f134 |display-authors=etal}}
- {{cite journal | vauthors=Thomas HR, Ezzeldin HH, Guarcello V |title=Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism. |journal=Pharmacogenet. Genomics |volume=17 |issue= 11 |pages= 973–87 |year= 2008 |pmid= 18075467 |doi= 10.1097/FPC.0b013e3282f01788 |display-authors=etal}}
- {{cite journal | vauthors=van Kuilenburg AB, Meijer J, Dobritzsch D |title=Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency. |journal=Mol. Genet. Metab. |volume=91 |issue= 2 |pages= 157–64 |year= 2007 |pmid= 17383919 |doi= 10.1016/j.ymgme.2007.02.008 |display-authors=etal}}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Fukada M, Watakabe I, Yuasa-Kawada J |title=Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37957–65 |year= 2001 |pmid= 10956643 |doi= 10.1074/jbc.M003277200 |display-authors=etal}}
- {{cite journal | vauthors=Hamajima N, Kouwaki M, Vreken P |title=Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene. |journal=Am. J. Hum. Genet. |volume=63 |issue= 3 |pages= 717–26 |year= 1998 |pmid= 9718352 |doi=10.1086/302022 | pmc=1377410 |display-authors=etal}}
- {{cite journal | vauthors=Naguib FN, el Kouni MH, Cha S |title=Enzymes of uracil catabolism in normal and neoplastic human tissues. |journal=Cancer Res. |volume=45 |issue= 11 Pt 1 |pages= 5405–12 |year= 1985 |pmid= 3931905 |doi= }}
{{refend}}{{Nucleotide metabolism enzymes}}{{gene-8-stub}} |