“DRG2”的意思、由来-开放百科全书

The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17.^[3]

References

1. ^{{cite journal | vauthors = Schenker T, Trueb B | title = Assignment of the gene for a developmentally regulated GTP-binding protein (DRG2) to human chromosome bands 17p13→p12 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 79 | issue = 3–4 | pages = 274–5 |date=Jun 1998 | pmid = 9605870 | pmc = | doi =10.1159/000134741 }}
2. ^{{cite journal | vauthors = Schenker T, Lach C, Kessler B, Calderara S, Trueb B | title = A novel GTP-binding protein which is selectively repressed in SV40 transformed fibroblasts | journal = J Biol Chem | volume = 269 | issue = 41 | pages = 25447–53 |date=Nov 1994 | pmid = 7929244 | pmc = | doi = }}
3. ^¹{{cite web | title = Entrez Gene: DRG2 developmentally regulated GTP binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1819| accessdate = }}

Further reading

{{cite journal | author=Sprang SR |title=G proteins, effectors and GAPs: structure and mechanism |journal=Curr. Opin. Struct. Biol. |volume=7 |issue= 6 |pages= 849–56 |year= 1998 |pmid= 9434906 |doi=10.1016/S0959-440X(97)80157-1 }}

{{cite journal | author=Liang Y |title=Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2 |journal=Genomics |volume=61 |issue= 3 |pages= 243–58 |year= 2000 |pmid= 10552926 |doi= 10.1006/geno.1999.5976 |name-list-format=vanc| author2=Wang A | author3=Belyantseva IA | display-authors=3 | last4=Anderson | first4=David W. | last5=Probst | first5=Frank J. | last6=Barber | first6=Thomas D. | last7=Miller | first7=Webb | last8=Touchman | first8=Jeffrey W. | last9=Jin | first9=Long |url=https://zenodo.org/record/1229792/files/article.pdf}}

{{cite journal | vauthors=Li B, Trueb B |title=DRG represents a family of two closely related GTP-binding proteins |journal=Biochim. Biophys. Acta |volume=1491 |issue= 1–3 |pages= 196–204 |year= 2000 |pmid= 10760581 |doi= 10.1016/s0167-4781(00)00025-7}}

{{cite journal | vauthors=Vlangos CN, Das P, Patel PI, Elsea SH |title=Assignment of developmentally regulated GTP-binding protein (DRG2) to human chromosome band 17p11.2 with somatic cell hybrids and localization to the Smith-Magenis syndrome critical interval |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3–4 |pages= 283–5 |year= 2000 |pmid= 10828610 |doi=10.1159/000015539 }}

{{cite journal | author=Bi W |title=Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse |journal=Genome Res. |volume=12 |issue= 5 |pages= 713–28 |year= 2002 |pmid= 11997338 |doi= 10.1101/gr.73702 | pmc=186594 |name-list-format=vanc| author2=Yan J | author3=Stankiewicz P | display-authors=3 | last4=Park | first4=SS | last5=Walz | first5=K | last6=Boerkoel | first6=CF | last7=Potocki | first7=L | last8=Shaffer | first8=LG | last9=Devriendt | first9=K }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Song H |title=Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis |journal=J. Biochem. |volume=135 |issue= 3 |pages= 331–5 |year= 2005 |pmid= 15113831 |doi=10.1093/jb/mvh040 |name-list-format=vanc| author2=Kim SI | author3=Ko MS | display-authors=3 | last4=Kim | first4=HJ | last5=Heo | first5=JC | last6=Lee | first6=HJ | last7=Lee | first7=HS | last8=Han | first8=IS | last9=Kwack | first9=K }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }}