| 释义 |
- References
{{enzyme
| Name = Dual-specificity kinase
| EC_number = 2.7.12.1
| CAS_number = 134549-83-0
| IUBMB_EC_number = 2/7/12/1
| GO_code =
| image =
| width =
| caption =
}}In biochemistry, a dual-specificity kinase ({{EC number|2.7.12.1}}) is a kinase that can act as both tyrosine kinase and serine/threonine kinase. MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include: - ADK1
- Arabidopsis dual specificity kinase 1
- CLK1, CLK2, CLK3, CLK4
- DSTYK
- DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4
- Mps1p
- TESK1, TESK2
- TTK
The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating). References- {{cite journal |vauthors=Dhanasekaran N, Premkumar Reddy E |year=1998 |title=Signaling by dual specificity kinases |journal=Oncogene |volume=17 |issue=11 Reviews |pages= 1447–1455 |pmid=9779990 |doi=10.1038/sj.onc.1202251}}
- {{cite journal |vauthors=Ali N, Halfter U, Chua NH | year = 1994 | title = Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine | journal = J. Biol. Chem. | volume = 269 | pages = 31626–9 | pmid = 7527390 | issue = 50 }}
- {{cite journal |vauthors=Lauze E, Stoelcker B, Luca FC, Weiss E, Schutz AR, Winey M | year = 1995 | title = Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase | journal = EMBO J. | volume = 14 | pages = 1655–63 | pmid = 7737118 | issue = 8 | pmc = 398258 }}
- {{cite journal |vauthors=Menegay HJ, Myers MP, Moeslein FM, Landreth GE | date = | title = Biochemical characterization and localization of the dual specificity kinase CLK1 | journal = J. Cell Sci. | volume = 113 | pages = 3241–53 | pmid = 10954422 }}
- {{cite journal | author = Cleghon V | year = 2003 | title = dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila | journal = Biochem. J. | volume = 374 | pages = 381–91 | pmid = 12786602 | doi = 10.1042/BJ20030500 | last2 = Sibbet | first2 = G | last3 = Kinstrie | first3 = R | last4 = Cleghon | first4 = T | last5 = Rylatt | first5 = M | last6 = Morrison | first6 = DK | last7 = Cleghon | first7 = V | issue = Pt 2 | pmc = 1223608 }}
{{Intracellular signaling peptides and proteins}}{{Kinases}}{{Serine/threonine-specific protein kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{2.7-enzyme-stub}} 2 : EC 2.7.12|Enzymes of unknown structure |