“Dyotropic reaction”的意思、由来-开放百科全书

A dyotropic Reaction (from the Greek dyo, meaning two) in organic chemistry is a type of organic reaction and more specifically a pericyclic valence isomerization in which two sigma bonds simultaneously migrate intramolecularly.^[1] The reaction type is of some relevance to organic chemistry because it can explain how certain reactions occur and because it is a synthetic tool in the synthesis of organic molecules for example in total synthesis. It was first described by Manfred T. Reetz in 1971 ^[2]^[3]

In a type I reaction two migrating groups interchange their relative positions and a type II reaction involves migration to new bonding sites without positional interchange.

Type I rearrangements

In type I rearrangements (Y-A-B-X conversion to X-A-B-Y) the two migrating groups are oriented trans to each other and as a result of the rearrangement they migrate to opposite sides. The first example of a dyotropic rearrangement involving a carbon-carbon bond was reported by Cyril A. Grob and Saul Winstein.^[4] They observed the interconversion of 2 bromine atoms in a certain steroid.

In a straightforward example the two bromine atoms in 3-tert-butyl-trans-1,2-dibromohexane mutarotate by heating.^[5] In the transition state both bromine atoms connect symmetrically to both carbon atoms on opposite sides and the reaction is concerted. Stepwise mechanisms in dyotropic reactions have also been investigated.

In organic synthesis an important application is the conversion of 4-substituted-gamma-lactones to butyrolactones. Type I dyotropic rearrangements also occur around carbon-oxygen bonds, such as the thermal equilibration of RRSi¹R₃C-O-Si²R₃ to RRSi²R₃C-O-Si¹R₃. The 1,2-Wittig rearrangement can also be considered an example of this reaction type. More dyotropic reactions are found involving N-O bonds and N-N bonds.

Type II rearrangements

Type II rearrangements often involve double hydrogen migration in a carbon skeleton. This reaction type can be found in certain transfer hydrogenations. An example is hydrogen transfer in syn-sesquinorbornene

References

1. ^Dyotropic Reactions: Mechanisms and Synthetic Applications Israel Fernandez Fernando P. Cossıo and Miguel A. Sierra Chem. Rev. 2009, Article ASAP {{DOI|10.1021/cr900209c}}
2. ^Dyotropic Rearrangements, a New Class of Orbital-Symmetry Controlled Reactions. Type I Manfred T. Reetz Angewandte Chemie International Edition in English 1971 Volume 11 Issue 2, Pages 129 - 130 {{DOI|10.1002/anie.197201291}}
3. ^Dyotropic Rearrangements, a New Class of Orbital-Symmetry Controlled Reactions. Type IIAngewandte Chemie International Edition in English 1971 Volume 11, Issue 2, Date: February 1972, Pages: 130-131 Manfred T. Reetz {{DOI|10.1002/anie.197201311}}
4. ^Organische und biologische Chemie Mechanismus der Mutarotation von 5,6-Dibromcholestan C.A. Grob, S. Winstein Helvetica Chimica Acta Volume 35 Issue 3, Pages 782 - 802 1952 {{DOI|10.1002/hlca.19520350315}}
5. ^Substituent effects on the formation and equilibration of trans-1,2-dibromocyclohexanes P. L. Barili, G. Bellucci, G. Berti, F. Marioni, A. Marsili, I. Morelli, J. Chem. Soc. D, 1970, (21),1437-1438 {{DOI|10.1039/C29700001437}}
6. ^Quantitation of proximity effects on rate. A case study involving dyotropic hydrogen migration within syn-sesquinorbornene disulfones carrying central substituents having different spatial demands Leo A. Paquette, Mark A. Kesselmayer, Robin D. Rogers J. Am. Chem. Soc., 1990, 112 (1), pp 284–291 {{DOI|10.1021/ja00157a044}}
7. ^Intramolecular reaction rate is not determined exclusively by the distance separating reaction centers. The kinetic consequences of modulated ground state strain on dyotropic hydrogen migration in systems of very similar geometric disposition Leo A. Paquette, George A. O'Doherty, Robin D. Rogers J. Am. Chem. Soc., 1991, 113 (20), pp 7761–7762 {{DOI|10.1021/ja00020a048}}