| 释义 |
- Function
- References
- Further reading
- External links
{{Infobox_gene}}Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.[1][2] Function This gene was identified by the induction of its expression in B lymphocytes by Epstein-Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.[3] EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.[4] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.[3][5] References1. ^{{cite web | title = Entrez Gene: EBI3 Epstein-Barr virus induced gene 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10148| accessdate = }}
2. ^{{cite journal | vauthors = Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M | title = A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes | journal = J. Virol. | volume = 70 | issue = 2 | pages = 1143–53 |date=February 1996 | pmid = 8551575 | pmc = 189923 | doi = | url = http://jvi.asm.org/cgi/content/abstract/70/2/1143 | issn = }}
3. ^1 {{cite journal | vauthors = Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA | title = The inhibitory cytokine IL-35 contributes to regulatory T-cell function | journal = Nature | volume = 450 | issue = 7169 | pages = 566–9 |date=November 2007 | pmid = 18033300 | doi = 10.1038/nature06306 | url = | issn = }}
4. ^{{cite journal | vauthors = Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N | title = Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells | journal = Nat. Immunol. | volume = 7 | issue = 9 | pages = 929–36 |date=September 2006 | pmid = 16906167 | doi = 10.1038/ni1375 | url = | issn = }}
5. ^{{cite journal | vauthors = Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY | title = IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells | journal = Eur. J. Immunol. | volume = 37 | issue = 11 | pages = 3021–9 |date=November 2007 | pmid = 17874423 | doi = 10.1002/eji.200737810 | url = | issn = }}
Further reading{{refbegin | 2}}- {{cite journal | author=Small RD |title=Letter: Statistical analysis of respiratory sensitivity to CO2. |journal=N. Engl. J. Med. |volume=295 |issue= 7 |pages= 397 |year= 1976 |pmid= 934235 |doi=10.1056/NEJM197608122950720 }}
- {{cite journal | vauthors=Devergne O, Hummel M, Koeppen H |title=A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. |journal=J. Virol. |volume=70 |issue= 2 |pages= 1143–53 |year= 1996 |pmid= 8551575 |doi= | pmc=189923 |display-authors=etal}}
- {{cite journal | vauthors=Devergne O, Birkenbach M, Kieff E |title=Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 22 |pages= 12041–6 |year= 1997 |pmid= 9342359 |doi=10.1073/pnas.94.22.12041 | pmc=23696 }}
- {{cite journal | vauthors=Pflanz S, Timans JC, Cheung J |title=IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. |journal=Immunity |volume=16 |issue= 6 |pages= 779–90 |year= 2002 |pmid= 12121660 |doi=10.1016/S1074-7613(02)00324-2 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Larousserie F, Pflanz S, Coulomb-L'Herminé A |title=Expression of IL-27 in human Th1-associated granulomatous diseases. |journal=J. Pathol. |volume=202 |issue= 2 |pages= 164–71 |year= 2004 |pmid= 14743498 |doi= 10.1002/path.1508 |display-authors=etal}}
- {{cite journal | vauthors=Grimwood J, Gordon LA, Olsen A |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |display-authors=etal}}
- {{cite journal | vauthors=Gehlert T, Devergne O, Niedobitek G |title=Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease. |journal=J. Med. Virol. |volume=73 |issue= 3 |pages= 432–8 |year= 2004 |pmid= 15170639 |doi= 10.1002/jmv.20109 }}
- {{cite journal | vauthors=Colland F, Jacq X, Trouplin V |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
{{refend}}External links- {{UCSC genome browser|EBI3}}
- {{UCSC gene details|EBI3}}
{{Interleukin receptor modulators}}{{gene-19-stub}} |