| 释义 |
- References
- Further reading
{{Infobox_gene}}Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene.[1][2]This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, Δ3,5-Δ2,4-dienoyl-CoA isomerase, contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.[2] References1. ^{{cite journal | vauthors = FitzPatrick DR, Germain-Lee E, Valle D | title = Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase | journal = Genomics | volume = 27 | issue = 3 | pages = 457–66 |date=Nov 1995 | pmid = 7558027 | pmc = | doi = 10.1006/geno.1995.1077 }}
2. ^1 {{cite web | title = Entrez Gene: ECH1 enoyl Coenzyme A hydratase 1, peroxisomal| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1891| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
- {{cite journal | vauthors=Kovalyov LI, Kovalyova MA, Kovalyov PL |title=Polymorphism of delta3,5-delta2,4-dienoyl-coenzyme A isomerase (the ECH1 gene product protein) in human striated muscle tissue. |journal=Biochemistry Mosc. |volume=71 |issue= 4 |pages= 448–53 |year= 2006 |pmid= 16615866 |doi=10.1134/S0006297906040146 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Goehler H, Lalowski M, Stelzl U |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 |display-authors=etal}}
- {{cite journal | vauthors=Jia Y, Qi C, Zhang Z |title=Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47232–9 |year= 2004 |pmid= 14500732 |doi= 10.1074/jbc.M306363200 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Filppula SA, Yagi AI, Kilpeläinen SH |title=Delta3,5-delta2,4-dienoyl-CoA isomerase from rat liver. Molecular characterization. |journal=J. Biol. Chem. |volume=273 |issue= 1 |pages= 349–55 |year= 1998 |pmid= 9417087 |doi=10.1074/jbc.273.1.349 |display-authors=etal}}
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