| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene.[1][2][3] Function This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases.[3] Interactions EEF1G has been shown to interact with: {{div col|colwidth=20em}}- EEF1B2,[5][4]
- EEF1D,[5][4]
- HARS,[5]
- LZTS1,[6]
- LARS,[5] and
- RECQL5.[7]
{{Div col end}} References 1. ^{{cite journal | vauthors = Kumabe T, Sohma Y, Yamamoto T | title = Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19 | journal = Nucleic Acids Res | volume = 20 | issue = 10 | pages = 2598 | date = July 1992 | pmid = 1598220 | pmc = 312399 | doi = 10.1093/nar/20.10.2598 }}
2. ^{{cite journal | vauthors = Sanders J, Maassen JA, Möller W | title = Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation | journal = Nucleic Acids Res | volume = 20 | issue = 22 | pages = 5907–10 | date = January 1993 | pmid = 1461723 | pmc = 334453 | doi = 10.1093/nar/20.22.5907 }}
3. ^1 {{cite web | title = Entrez Gene: EEF1G eukaryotic translation elongation factor 1 gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1937| accessdate = }}
4. ^1 {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
5. ^1 {{cite journal | vauthors = Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S | title = Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex | journal = Biochem. Biophys. Res. Commun. | volume = 291 | issue = 1 | pages = 158–64 | date = February 2002 | pmid = 11829477 | doi = 10.1006/bbrc.2002.6398 }}
6. ^{{cite journal | vauthors = Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM | title = FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 18 | pages = 10374–9 | date = August 2001 | pmid = 11504921 | pmc = 56968 | doi = 10.1073/pnas.181222898 }}
7. ^1 2 {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = September 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
{{Clear}} Further reading {{refbegin | 2}}- {{cite journal | vauthors = Lew Y, Jones DV, Mars WM, Evans D, Byrd D, Frazier ML | title = Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. | journal = Pancreas | volume = 7 | issue = 2 | pages = 144–52 | year = 1992 | pmid = 1372736 | doi = 10.1097/00006676-199203000-00003 }}
- {{cite journal | vauthors = Koonin EV, Mushegian AR, Tatusov RL, Altschul SF, Bryant SH, Bork P, Valencia A | title = Eukaryotic translation elongation factor 1 gamma contains a glutathione transferase domain--study of a diverse, ancient protein superfamily using motif search and structural modeling. | journal = Protein Sci. | volume = 3 | issue = 11 | pages = 2045–54 | year = 1995 | pmid = 7703850 | pmc = 2142650 | doi = 10.1002/pro.5560031117 }}
- {{cite journal | vauthors = Sheu GT, Traugh JA | title = Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII. | journal = J. Biol. Chem. | volume = 272 | issue = 52 | pages = 33290–7 | year = 1998 | pmid = 9407120 | doi = 10.1074/jbc.272.52.33290 }}
- {{cite journal | vauthors = Sheu GT, Traugh JA | title = A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII. | journal = Mol. Cell. Biochem. | volume = 191 | issue = 1-2 | pages = 181–6 | year = 1999 | pmid = 10094407 | doi = 10.1023/A:1006802125856 }}
- {{cite journal | vauthors = Kim JE, Kim KH, Lee SW, Seol W, Shiba K, Kim S | title = An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing. | journal = Nucleic Acids Res. | volume = 28 | issue = 15 | pages = 2866–72 | year = 2000 | pmid = 10908348 | pmc = 102683 | doi = 10.1093/nar/28.15.2866 }}
- {{cite journal | vauthors = Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM | title = FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 18 | pages = 10374–9 | year = 2001 | pmid = 11504921 | pmc = 56968 | doi = 10.1073/pnas.181222898 }}
- {{cite journal | vauthors = Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S | title = Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. | journal = Biochem. Biophys. Res. Commun. | volume = 291 | issue = 1 | pages = 158–64 | year = 2002 | pmid = 11829477 | doi = 10.1006/bbrc.2002.6398 }}
- {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. | journal = Nat. Biotechnol. | volume = 21 | issue = 5 | pages = 566–9 | year = 2004 | pmid = 12665801 | doi = 10.1038/nbt810 }}
- {{cite journal | vauthors = Vanwetswinkel S, Kriek J, Andersen GR, Dijk J, Siegal G | title = 1H, 15N and 13C resonance assignments of the highly conserved 19 kDa C-terminal domain from human elongation factor 1Bgamma. | journal = J. Biomol. NMR | volume = 26 | issue = 2 | pages = 189–90 | year = 2004 | pmid = 12766415 | doi = 10.1023/A:1023504611632 }}
- {{cite journal | vauthors = Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, MacDonald PN | title = Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. | journal = J. Biol. Chem. | volume = 278 | issue = 37 | pages = 35325–36 | year = 2003 | pmid = 12840015 | doi = 10.1074/jbc.M305191200 }}
- {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway. | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
- {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. | journal = Curr. Biol. | volume = 14 | issue = 16 | pages = 1436–50 | year = 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
- {{cite journal | vauthors = Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE | title = A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. | journal = Mol. Cell | volume = 15 | issue = 6 | pages = 853–65 | year = 2004 | pmid = 15383276 | doi = 10.1016/j.molcel.2004.09.016 }}
- {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics. | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
{{refend}}{{PDB Gallery|geneid=1937}}{{protein-stub}} |