| 词条 | EGLU |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 444652213 | IUPAC_name = (2S)-2-Amino-2-ethylpentanedioic acid | image = Salpha_ethylglutamic_acid.png | width = 200 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 5311079 | IUPHAR_ligand = 1400 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4470613 | smiles = O=C(O)CC[C@](N)(C(=O)O)CC | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C7H13NO4/c1-2-7(8,6(11)12)4-3-5(9)10/h2-4,8H2,1H3,(H,9,10)(H,11,12)/t7-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = QFYBYZLHPIALCZ-ZETCQYMHSA-N | C=7 | H=13 | N=1 | O=4 | molecular_weight = 175.182 g/mol }}EGLU ((2S)-α-ethylglutamic acid ) is a drug that is used in neuroscience research. It was one of the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and so has been useful in the characterization and study of this receptor subfamily.[1][2][3][4][5][6][7] References1. ^{{cite journal | last1 = Jane | first1 = DE | last2 = Thomas | first2 = NK | last3 = Tse | first3 = HW | last4 = Watkins | first4 = JC | title = Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord | journal = Neuropharmacology | volume = 35 | issue = 8 | pages = 1029–35 | year = 1996 | pmid = 9121605 | doi=10.1016/S0028-3908(96)00048-2}} {{Metabotropic glutamate receptor modulators}}{{nervous-system-drug-stub}}2. ^{{cite journal | last1 = Huang | first1 = L | last2 = Rowan | first2 = MJ | last3 = Anwyl | first3 = R | title = Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro | journal = European Journal of Pharmacology | volume = 366 | issue = 2–3 | pages = 151–8 | year = 1999 | pmid = 10082195 | doi=10.1016/S0014-2999(98)00918-2}} 3. ^{{cite journal | last1 = Palazzo | first1 = E | last2 = Marabese | first2 = I | last3 = De Novellis | first3 = V | last4 = Oliva | first4 = P | last5 = Rossi | first5 = F | last6 = Berrino | first6 = L | last7 = Rossi | first7 = F | last8 = Maione | first8 = S | title = Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception | journal = Neuropharmacology | volume = 40 | issue = 3 | pages = 319–26 | year = 2001 | pmid = 11166324 | doi=10.1016/S0028-3908(00)00160-X}} 4. ^{{cite journal | last1 = Iserhot | first1 = C | last2 = Gebhardt | first2 = C | last3 = Schmitz | first3 = D | last4 = Heinemann | first4 = U | title = Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat | journal = Brain Research | volume = 1027 | issue = 1–2 | pages = 151–60 | year = 2004 | pmid = 15494166 | doi = 10.1016/j.brainres.2004.08.052 }} 5. ^{{cite journal | last1 = Cahusac | first1 = PM | last2 = Wan | first2 = H | title = Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo | journal = Neuroscience | volume = 146 | issue = 1 | pages = 202–12 | year = 2007 | pmid = 17346894 | doi = 10.1016/j.neuroscience.2007.01.049 }} 6. ^{{cite journal | last1 = Kim | first1 = WY | last2 = Vezina | first2 = P | last3 = Kim | first3 = JH | title = Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment | journal = Behavioural Brain Research | volume = 191 | issue = 1 | pages = 62–6 | year = 2008 | pmid = 18433894 | doi = 10.1016/j.bbr.2008.03.010 }} 7. ^{{cite journal | last1 = Altinbilek | first1 = B | last2 = Manahan-Vaughan | first2 = D | title = A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory | journal = Neuroscience | volume = 158 | issue = 1 | pages = 149–58 | year = 2009 | pmid = 18722513 | doi = 10.1016/j.neuroscience.2008.07.045 }} 4 : MGlu2 receptor antagonists|MGlu3 receptor antagonists|Amino acids|Dicarboxylic acids |
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