“EHD1”的意思、由来-开放百科全书

EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1 gene^[1] belonging to the EHD protein family.

Function

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.^[1]

Interactions

EHD1 has been shown to interact with Insulin-like growth factor 1 receptor^[2] and SNAP29.^[2]

References

1. ^¹{{cite web | title = Entrez Gene: EHD1 EH-domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10938| accessdate = }}
2. ^¹{{cite journal |last=Rotem-Yehudar |first=R |author2=Galperin E |author3=Horowitz M |date=Aug 2001 |title=Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 |journal=J. Biol. Chem. |volume=276 |issue=35 |pages=33054–60 |publisher= |location = United States| issn = 0021-9258| pmid = 11423532 |doi = 10.1074/jbc.M009913200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}

Further reading

{{cite journal | vauthors=Di Fiore PP, Pelicci PG, Sorkin A |title=EH: a novel protein-protein interaction domain potentially involved in intracellular sorting |journal=Trends Biochem. Sci. |volume=22 |issue= 11 |pages= 411–3 |year= 1998 |pmid= 9397678 |doi=10.1016/S0968-0004(97)01127-4 }}

{{cite journal | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-format=vanc| author2=Wentland MA | author3=Ricafrente JY | display-authors=3 | last4=Liu | first4=W | last5=Gibbs | first5=RA }}

{{cite journal | author=Yu W |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |name-list-format=vanc| author2=Andersson B | author3=Worley KC | display-authors=3 | last4=Muzny | first4=DM | last5=Ding | first5=Y | last6=Liu | first6=W | last7=Ricafrente | first7=JY | last8=Wentland | first8=MA | last9=Lennon | first9=G }}

{{cite journal | author=Guru SC |title=A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus |journal=Genome Res. |volume=7 |issue= 7 |pages= 725–35 |year= 1997 |pmid= 9253601 |doi= 10.1101/gr.7.7.725| pmc=310681 |name-list-format=vanc| author2=Agarwal SK | author3=Manickam P | display-authors=3 | last4=Olufemi | first4=SE | last5=Crabtree | first5=JS | last6=Weisemann | first6=JM | last7=Kester | first7=MB | last8=Kim | first8=YS | last9=Wang | first9=Y }}

{{cite journal | author=Mintz L |title=EHD1--an EH-domain-containing protein with a specific expression pattern |journal=Genomics |volume=59 |issue= 1 |pages= 66–76 |year= 1999 |pmid= 10395801 |doi= 10.1006/geno.1999.5800 |name-list-format=vanc| author2=Galperin E | author3=Pasmanik-Chor M | display-authors=3 | last4=Tulzinsky | first4=Sandra | last5=Bromberg | first5=Yael | last6=Kozak | first6=Christine A. | last7=Joyner | first7=Alexandra | last8=Fein | first8=Amos | last9=Horowitz | first9=Mia }}

{{cite journal | author=Haider NB |title=Evaluation and molecular characterization of EHD1, a candidate gene for Bardet-Biedl syndrome 1 (BBS1) |journal=Gene |volume=240 |issue= 1 |pages= 227–32 |year= 2000 |pmid= 10564830 |doi=10.1016/S0378-1119(99)00395-9 |name-list-format=vanc| author2=Searby C | author3=Galperin E | display-authors=3 | last4=Mintz | first4=L. | last5=Horowitz | first5=M. | last6=Stone | first6=E.M. | last7=Sheffield | first7=V.C. }}

{{cite journal | author=Pohl U |title=EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins |journal=Genomics |volume=63 |issue= 2 |pages= 255–62 |year= 2000 |pmid= 10673336 |doi= 10.1006/geno.1999.6087 |name-list-format=vanc| author2=Smith JS | author3=Tachibana I | display-authors=3 | last4=Ueki | first4=Keisuke | last5=Lee | first5=Hyun K. | last6=Ramaswamy | first6=Shivapriya | last7=Wu | first7=Qiang | last8=Mohrenweiser | first8=Harvey W. | last9=Jenkins | first9=Robert B. }}

{{cite journal | vauthors=Rotem-Yehudar R, Galperin E, Horowitz M |title=Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33054–60 |year= 2001 |pmid= 11423532 |doi= 10.1074/jbc.M009913200 }}

{{cite journal | author=Caplan S |title=A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane |journal=EMBO J. |volume=21 |issue= 11 |pages= 2557–67 |year= 2002 |pmid= 12032069 |doi= 10.1093/emboj/21.11.2557 | pmc=126039 |name-list-format=vanc| author2=Naslavsky N | author3=Hartnell LM | display-authors=3 | last4=Lodge | first4=R | last5=Polishchuk | first5=RS | last6=Donaldson | first6=JG | last7=Bonifacino | first7=JS }}

{{cite journal | author=Galperin E |title=EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1 |journal=Traffic |volume=3 |issue= 8 |pages= 575–89 |year= 2003 |pmid= 12121420 |doi=10.1034/j.1600-0854.2002.30807.x |name-list-format=vanc| author2=Benjamin S | author3=Rapaport D | display-authors=3 | last4=Rotem-Yehudar | first4=Rinat | last5=Tolchinsky | first5=Sandra | last6=Horowitz | first6=Mia }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}}

{{cite journal | author=Gevaert K |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |name-list-format=vanc| author2=Goethals M | author3=Martens L | display-authors=3 | last4=Van Damme | first4=Jozef | last5=Staes | first5=An | last6=Thomas | first6=Grégoire R. | last7=Vandekerckhove | first7=Joël }}

{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}

{{cite journal | vauthors=Naslavsky N, Boehm M, Backlund PS, Caplan S |title=Rabenosyn-5 and EHD1 Interact and Sequentially Regulate Protein Recycling to the Plasma Membrane |journal=Mol. Biol. Cell |volume=15 |issue= 5 |pages= 2410–22 |year= 2005 |pmid= 15020713 |doi= 10.1091/mbc.E03-10-0733 | pmc=404033 }}

{{cite journal | vauthors=Guilherme A, Soriano NA, Furcinitti PS, Czech MP |title=Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40062–75 |year= 2004 |pmid= 15247266 |doi= 10.1074/jbc.M401918200 }}

{{cite journal | author=Xu Y |title=Mutually exclusive interactions of EHD1 with GS32 and syndapin II |journal=Mol. Membr. Biol. |volume=21 |issue= 4 |pages= 269–77 |year= 2005 |pmid= 15371016 |doi= 10.1080/09687680410001716871 |name-list-format=vanc| author2=Shi H | author3=Wei S | display-authors=3 | last4=Wong | first4=Siew Heng | last5=Hong | first5=Wanjin }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Lee DW |title=ATP binding regulates oligomerization and endosome association of RME-1 family proteins |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 17213–20 |year= 2005 |pmid= 15710626 |doi= 10.1074/jbc.M412751200 |name-list-format=vanc| author2=Zhao X | author3=Scarselletta S | display-authors=3 | last4=Schweinsberg | first4=PJ | last5=Eisenberg | first5=E | last6=Grant | first6=BD | last7=Greene | first7=LE }}

{{cite journal | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B | author3=Gnad F | display-authors=3 | last4=Macek | first4=Boris | last5=Kumar | first5=Chanchal | last6=Mortensen | first6=Peter | last7=Mann | first7=Matthias }}

1 : EH-domain-containing proteins