| 词条 | Ehrlichiosis ewingii infection |
| 释义 |
| name = Human ewingii ehrlichiosis | synonyms = | image = | caption = | pronounce = | field = infectious disease | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} Ehrlichiosis ewingii infection[1] is an infectious disease caused by an intracellular bacteria, Ehrlichia ewingii.[2] The infection is transmitted to humans by the tick, Amblyomma americanum. This tick can also transmit Ehrlichia chaffeensis, the bacteria that causes human monocytic ehrlichiosis (HME). SymptomsPatients can present with fever, headache, myalgias, and malaise. Laboratory tests may reveal thrombocytopenia, leukopenia, and evidence of liver damage. MechanismHumans contract the disease after a bite by an infected tick of the species Amblyomma americanum.{{citation needed|date=January 2017}} Those with an underlying immunodeficiency (such as HIV) appear to be at greater risk of contracting the disease. Compared to HME, ewingii ehrlichiosis has a decreased incidence of complications.[3] Like Anaplasma phagocytophilum, the causative agent of human granulocytic ehrlichiosis, Ehrlichia ewingii infects neutrophils. Infection with E. ewingii may delay neutrophil apoptosis.[4] DiagnosisIn endemic areas, a high index of suspicion is warranted, especially with a known exposure to ticks. The diagnosis can be confirmed by using PCR.[5] A peripheral blood smear can also be examined for intracytoplasmic inclusions called morulae. TreatmentThe treatment of choice is doxycycline. See also
References1. ^{{cite book |author1=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages=1130 |isbn=1-4160-2999-0 |oclc= |doi= |accessdate=}} 2. ^{{cite journal |author=Patnaik MM |title=Inclusion bodies in tick-borne diseases diagnosed in patients from northern Wisconsin |journal=Clin Med Res |volume=7 |issue=1-2 |pages=45–7 |date=June 2009 |pmid=19574488 |pmc=2705270 |doi=10.3121/cmr.2009.807.818 |url=http://www.clinmedres.org/cgi/pmidlookup?view=long&pmid=19574488}} 3. ^{{cite journal |vauthors=Paddock CD, Folk SM, Shore GM, etal |title=Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus |journal=Clinical Infectious Diseases |volume=33 |issue=9 |pages=1586–94 |date=November 2001 |pmid=11568857 |doi=10.1086/323981 |url=http://www.journals.uchicago.edu/cgi-bin/resolve?CID010310}} 4. ^{{cite journal |vauthors=Xiong Q, Bao W, Ge Y, Rikihisa Y |title=Ehrlichia ewingii infection delays spontaneous neutrophil apoptosis through stabilization of mitochondria |journal=The Journal of Infectious Diseases |volume=197 |issue=8 |pages=1110–8 |date=April 2008 |pmid=18462160 |doi=10.1086/533457 |url=}} 5. ^{{cite journal|pmid=11682500|date=Nov 2001|title=Identification of a p28 gene in Ehrlichia ewingii: evaluation of gene for use as a target for a species-specific PCR diagnostic assay.|volume=39|issue=11|pages=3871–6|pmc=88457|doi=10.1128/JCM.39.11.3871-3876.2001|journal=Journal of Clinical Microbiology|url=http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=11682500|format=Free full text|author1=Gusa, Aa|author2=Buller, Rs|author3=Storch, Ga|author4=Huycke, Mm|author5=MacHado, Lj|author6=Slater, Ln|author7=Stockham, Sl|author8=Massung, Rf}} External links{{Medical resources| DiseasesDB = | ICD10 = | ICD9 = {{ICD9|082.4}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = med | eMedicineTopic = 3391 | eMedicine_mult = {{eMedicine2|ped|655}} {{eMedicine2|emerg|159}} | MeshID = }}{{Bacterial diseases}}{{Tick-borne diseases}} 2 : Bacterium-related cutaneous conditions|Tick-borne diseases |
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