| 词条 | Ehrlich's reagent |
| 释义 |
Ehrlich's reagent or Ehrlich reagent is a reagent that contains p-dimethylaminobenzaldehyde (DMAB) and thus can act as an indicator to presumptively identify indoles and urobilinogen. Several Ehrlich tests use the reagent in a medical test; some are drug tests and others contribute to diagnosis of various diseases or adverse drug reactions. A very common Ehrlich test is a simple spot test to identify possible psychoactive compounds such as tryptamines (e.g. DMT) and ergoloids (e.g. LSD). The reagent will also give a positive result for opium, despite the opiates not containing the indole functional group, because of the presence of tryptophan in natural opium.[1] It is named after Nobel Prize winner Paul Ehrlich who used it to distinguish typhoid from simple diarrhoea. The reagent is prepared by dissolving 0.5[2]–2.0 g of p–dimethylaminobenzaldehyde (DMAB) in 50 mL of 95% ethanol and 50 mL of concentrated hydrochloric acid[3][4] and is best used when fresh. Other alcohols, such as 1-propanol, can also be used as well.[5] The Ehrlich reagent is similar to a number of other indole tests:
The Ehrlich reagent works by binding to the C2 position of two indole moieties to form a resonance stabilised carbenium ion compound.[8] See also
References1. ^1 {{cite journal|last1=de Faubert Maunder|first1=MJ|title=Field and laboratory test for raw and prepared opium.|journal=Bulletin on narcotics|date=|volume=27|issue=1|pages=71–6|pmid=1039285|url=http://www.unodc.org/unodc/en/data-and-analysis/bulletin/bulletin_1975-01-01_1_page008.html|year=1975}} 2. ^{{cite journal | title = Analytical Profiles for Five "Designer" Tryptamines | journal = Microgram Journal | date = 2004 | first = Trinette | last = Spratley | volume = 3 | issue = 1–2 | pages = 55| id = | url = http://www.erowid.org/library/periodicals/microgram/microgram_journal_2005-1.pdf#page=54 | format = PDF | accessdate = 2013-10-09}} 3. ^{{cite journal|last1=O’Neal|first1=Carol L|last2=Crouch|first2=Dennis J|last3=Fatah|first3=Alim A|title=Validation of twelve chemical spot tests for the detection of drugs of abuse|journal=Forensic Science International|date=April 2000|volume=109|issue=3|pages=189–201|doi=10.1016/S0379-0738(99)00235-2|pmid=10725655}} 4. ^{{cite web|title=Color Test Reagents/Kits for Preliminary Identification of Drugs of Abuse|url=http://www.ncjrs.gov/pdffiles1/nij/183258.pdf|work=Law Enforcement and Corrections Standards and Testing Program|accessdate=2011-07-24|format=PDF|date=July 2000}} 5. ^{{cite web | url=http://www.labchem.com/tools/msds/msds/LC14080.pdf | title=Ehrlich's Reagent Safety Data Sheet | publisher=Labchem | accessdate=11 January 2015 | author=02 July 2014}} 6. ^{{Cite journal | last1 = Ehmann | first1 = A. | title = The van URK-Salkowski reagent — a sensitive and specific chromogenic reagent for silica gel thin-layer chromatographic detection and identification of indole derivatives | doi = 10.1016/S0021-9673(00)89300-0 | journal = Journal of Chromatography A | volume = 132 | issue = 2 | pages = 267–276| year = 1977 | pmid = | pmc = | url = https://erowid.org/psychoactives/testing/testing_field_article2.pdf}} 7. ^{{cite journal|last1=Maunder|first1=M. J. de Faubert|title=A field test for hallucinogens: further improvements|journal=Journal of Pharmacy and Pharmacology|date=August 1974|volume=26|issue=8|pages=637–638|doi=10.1111/j.2042-7158.1974.tb10677.x}} 8. ^{{cite web | url=https://www.unodc.org/pdf/scientific/SCITEC6.pdf | title=Chemistry and Reaction Mechanisms of Rapid Tests for Drugs of Abuse and Precursors Chemicals | publisher=UNODC | date=February 1989 | accessdate=3 January 2016 |author1=Kovar, Karl-Artur |author2=Laudszun, Martina | pages=15}} External links{{chem-stub}} 4 : Chemical tests|Analytical reagents|Drug testing reagents|Paul Ehrlich |
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