1. Function

2. See also

3. References

4. Further reading

Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene.^[1][2][3] The eIF2A protein is not to be confused with eIF2α, a subunit of the heterotrimeric eIF2 complex. Instead, eIF2A functions by a separate mechanism in eukaryotic translation.

Function

eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]^[3] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated.^[4][5]

See also

• eIF2

References

Further reading

• {{cite journal | vauthors = Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG | title = Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha | journal = Molecular and Cellular Biology | volume = 22 | issue = 21 | pages = 7405–16 | date = Nov 2002 | pmid = 12370288 | pmc = 135664 | doi = 10.1128/MCB.22.21.7405-7416.2002 }}
• {{cite journal | vauthors = Page AB, Owen CR, Kumar R, Miller JM, Rafols JA, White BC, DeGracia DJ, Krause GS | title = Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia | journal = Acta Neuropathologica | volume = 106 | issue = 1 | pages = 8–16 | date = Jul 2003 | pmid = 12687390 | doi = 10.1007/s00401-003-0693-2 }}
• {{cite journal | vauthors = Ito T, Marintchev A, Wagner G | title = Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B | journal = Structure | volume = 12 | issue = 9 | pages = 1693–704 | date = Sep 2004 | pmid = 15341733 | doi = 10.1016/j.str.2004.07.010 }}
• {{cite journal | vauthors = Weiser DC, Sikes S, Li S, Shenolikar S | title = The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms | journal = The Journal of Biological Chemistry | volume = 279 | issue = 47 | pages = 48904–14 | date = Nov 2004 | pmid = 15345721 | doi = 10.1074/jbc.M404416200 }}
• {{cite journal | vauthors = Komar AA, Gross SR, Barth-Baus D, Strachan R, Hensold JO, Goss Kinzy T, Merrick WC | title = Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A | journal = The Journal of Biological Chemistry | volume = 280 | issue = 16 | pages = 15601–11 | date = Apr 2005 | pmid = 15718232 | doi = 10.1074/jbc.M413728200 }}
• {{cite journal | vauthors = Wang J, Laschinger C, Zhao XH, Mak B, Seth A, McCulloch CA | title = Mechanical force activates eIF-2alpha phospho-kinases in fibroblast | journal = Biochemical and Biophysical Research Communications | volume = 330 | issue = 1 | pages = 123–30 | date = Apr 2005 | pmid = 15781241 | doi = 10.1016/j.bbrc.2005.02.140 }}
• {{cite journal | vauthors = Gorrini C, Loreni F, Gandin V, Sala LA, Sonenberg N, Marchisio PC, Biffo S | title = Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 26 | pages = 9200–5 | date = Jun 2005 | pmid = 15961545 | pmc = 1166589 | doi = 10.1073/pnas.0409513102 }}
• {{cite journal | vauthors = Su Q, Wang S, Baltzis D, Qu LK, Wong AH, Koromilas AE | title = Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 1 | pages = 63–8 | date = Jan 2006 | pmid = 16373505 | pmc = 1324992 | doi = 10.1073/pnas.0508207103 }}
• {{cite journal | vauthors = Squatrito M, Mancino M, Sala L, Draetta GF | title = Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation | journal = Biochemical and Biophysical Research Communications | volume = 344 | issue = 3 | pages = 859–68 | date = Jun 2006 | pmid = 16631606 | doi = 10.1016/j.bbrc.2006.03.205 }}
• {{cite journal | vauthors = Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ | title = Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis | journal = The Journal of Biological Chemistry | volume = 281 | issue = 30 | pages = 21458–68 | date = Jul 2006 | pmid = 16717090 | doi = 10.1074/jbc.M603784200 }}
• {{cite journal | vauthors = Mazroui R, Sukarieh R, Bordeleau ME, Kaufman RJ, Northcote P, Tanaka J, Gallouzi I, Pelletier J | title = Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation | journal = Molecular Biology of the Cell | volume = 17 | issue = 10 | pages = 4212–9 | date = Oct 2006 | pmid = 16870703 | pmc = 1635342 | doi = 10.1091/mbc.E06-04-0318 }}
• {{cite journal | vauthors = Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY | title = Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa | journal = The Journal of Biological Chemistry | volume = 281 | issue = 42 | pages = 31440–7 | date = Oct 2006 | pmid = 16928686 | doi = 10.1074/jbc.M604356200 }}
• {{cite journal | vauthors = Fritsch RM, Schneider G, Saur D, Scheibel M, Schmid RM | title = Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation | journal = The Journal of Biological Chemistry | volume = 282 | issue = 31 | pages = 22551–62 | date = Aug 2007 | pmid = 17553788 | doi = 10.1074/jbc.M702673200 }}
• {{cite journal | vauthors = Nayak R, Pintel DJ | title = Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA | journal = Journal of Virology | volume = 81 | issue = 21 | pages = 11908–16 | date = Nov 2007 | pmid = 17715234 | pmc = 2168773 | doi = 10.1128/JVI.01132-07 }}

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