“ENSA (gene)”的意思、由来-开放百科全书

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.^[2]

References

1. ^{{cite journal | vauthors = Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D | title = Human α-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: Molecular cloning, expression and biological properties | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 14 | pages = 8387–91 |date=Aug 1998 | pmid = 9653196 | pmc = 20985 | doi =10.1073/pnas.95.14.8387 }}
2. ^¹{{cite web | title = Entrez Gene: ENSA endosulfine alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2029| accessdate = }}

Further reading

{{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}

{{cite journal | author=Héron L |title=Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels |journal=Diabetes |volume=48 |issue= 9 |pages= 1873–6 |year= 1999 |pmid= 10480622 |doi=10.2337/diabetes.48.9.1873 |name-list-format=vanc| author2=Virsolvy A | author3=Apiou F | display-authors=3 | last4=Le Cam | first4=A. | last5=Bataille | first5=D. }}

{{cite journal | author=Zhang QH |title=Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 |name-list-format=vanc| author2=Ye M | author3=Wu XY | display-authors=3 | last4=Ren | first4=SX | last5=Zhao | first5=M | last6=Zhao | first6=CJ | last7=Fu | first7=G | last8=Shen | first8=Y | last9=Fan | first9=HY }}

{{cite journal | vauthors=Kim SH, Lubec G |title=Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 1–9 |year= 2002 |pmid= 11771735 |doi= 10.1007/978-3-7091-6262-0_1}}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Bataille D |title=Endosulfines: Novel regulators of insulin secretion |journal=Drug News Perspect. |volume=13 |issue= 8 |pages= 453–62 |year= 2003 |pmid= 12937617 |doi= }}

{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}

{{cite journal | author=Wang H |title=Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion |journal=Mol. Genet. Metab. |volume=81 |issue= 1 |pages= 9–15 |year= 2004 |pmid= 14728986 |doi=10.1016/j.ymgme.2003.08.003 |name-list-format=vanc| author2=Craig RL | author3=Schay J | display-authors=3 | last4=Chu | first4=W | last5=Das | first5=SK | last6=Zhang | first6=Z | last7=Elbein | first7=SC }}

{{cite journal | author=Thameem F |title=The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians |journal=Mol. Genet. Metab. |volume=81 |issue= 1 |pages= 16–21 |year= 2004 |pmid= 14728987 |doi=10.1016/j.ymgme.2003.09.013 |name-list-format=vanc| author2=Farook VS | author3=Yang X | display-authors=3 | last4=Lee | first4=YH | last5=Permana | first5=PA | last6=Bogardus | first6=C | last7=Prochazka | first7=M }}

{{cite journal | author=Gabrielsson BG |title=Molecular characterization of a local sulfonylurea system in human adipose tissue |journal=Mol. Cell. Biochem. |volume=258 |issue= 1–2 |pages= 65–71 |year= 2004 |pmid= 15030171 |doi=10.1023/B:MCBI.0000012837.11847.c8 |name-list-format=vanc| author2=Karlsson AC | author3=Lönn M | display-authors=3 | last4=Olofsson | first4=Louise E. | last5=Johansson | first5=Jenny M. | last6=Torgerson | first6=Jarl S. | last7=Sjöström | first7=Lars | last8=Carlsson | first8=Björn | last9=Edén | first9=Staffan }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B | author3=Gnad F | display-authors=3 | last4=Macek | first4=Boris | last5=Kumar | first5=Chanchal | last6=Mortensen | first6=Peter | last7=Mann | first7=Matthias }}

{{cite journal | author=Ewing RM |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |name-list-format=vanc| author2=Chu P | author3=Elisma F | display-authors=3 | last4=Li | first4=Hongyan | last5=Taylor | first5=Paul | last6=Climie | first6=Shane | last7=McBroom-Cerajewski | first7=Linda | last8=Robinson | first8=Mark D | last9=O'Connor | first9=Liam }}