| 词条 | Eosinophilic cellulitis |
| 释义 |
| name = Eosinophilic cellulitis | synonyms = Wells' syndrome, recurrent granulomatous dermatitis with eosinophilia[1] | image = SkinInEosinCell.jpg | caption = Initial rash in eosinophilic cellulitis | pronounce = | field = Dermatology | symptoms = Painful, red, raised, warm patches of skin[2] | complications = | onset = Sudden and recurrent[2] | duration = Few weeks[2] | causes = Unknown[2] | risks = | diagnosis = | differential = Vasculitis, cellulitis, anaphylaxis[2][1] | prevention = | treatment = | medication = Corticosteroids, antihistamines[2][1] | prognosis = Often goes away by itself[2] | frequency = ~200 documented cases[1] | deaths = }}Eosinophilic cellulitis, also known as Wells' syndrome, is a skin disease that presents with painful, red, raised, and warm patches of skin.[2] The rash comes on suddenly, lasts for a few weeks, and often repeatedly comes back.[2] Scar formation does not typically occur.[1] Eosinophilic cellulitis is of unknown cause.[2] It is suspected to be an autoimmune disorder.[2] It may be triggered by bites from insects such as spiders, fleas, or ticks, or from medications or surgery.[2] Diagnosis is made after other potential cases are ruled out.[1] Skin biopsy of the affected areas may show an increased number of eosinophils.[2] Other conditions that may appear similar include cellulitis, contact dermatitis, and severe allergic reactions such as anaphylaxis.[2] Treatment is often with a corticosteroids.[2] Steroids applied as a cream is generally recommended over the use of steroids by mouth.[22] Antihistamines may be used to help with itchiness.[1] Many times the condition goes away after a few weeks without treatment.[2] The condition is uncommon.[1] It affects both sexes with the same frequency.[2] It was first described by George Crichton Wells in 1971.[3][1] CauseEosinophilic cellulitis is of unknown cause.[2] It is suspected to be an autoimmune disorder.[2] It may be triggered by bites from insects such as mosquitos,[4] spiders, fleas, or ticks, or from medications or surgery.[2] DiagnosisDiagnosis requires ruling out other potential causes.[1] This includes ruling out vasculitis on skin biopsy.[1] TreatmentTreatment is often with a steroids.[2] This can be either applied as a cream or taken by mouth.[22] As the condition tends to get better on its own taking steroids by mouth should generally only be tried if the rash covers a large area and it does not get better with other measures.[5] References1. ^1 2 3 4 5 6 7 8 9 10 {{cite journal|last1=Weins|first1=AB|last2=Biedermann|first2=T|last3=Weiss|first3=T|last4=Weiss|first4=JM|title=Wells syndrome.|journal=Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG|date=October 2016|volume=14|issue=10|pages=989–993|pmid=27767278|doi=10.1111/ddg.13132}} 2. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 {{cite web|title=Familial Eosinophilic Cellulitis - NORD (National Organization for Rare Disorders)|url=http://rarediseases.org/rare-diseases/familial-eosinophilic-cellulitis/|website=NORD (National Organization for Rare Disorders)|accessdate=10 April 2017|date=2009}} 3. ^{{cite book |author1=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages= |isbn=1-4160-2999-0}} 4. ^{{cite journal | vauthors = Tatsuno K, Fujiyama T, Matsuoka H, Shimauchi T, Ito T, Tokura Y | title = Clinical categories of exaggerated skin reactions to mosquito bites and their pathophysiology | journal = Journal of Dermatological Science | volume = 82 | issue = 3 | pages = 145–52 | date = June 2016 | pmid = 27177994 | doi = 10.1016/j.jdermsci.2016.04.010 | url = }} 5. ^1 2 {{cite journal|last1=Räßler|first1=F|last2=Lukács|first2=J|last3=Elsner|first3=P|title=Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.|journal=Journal of the European Academy of Dermatology and Venereology : JEADV|date=September 2016|volume=30|issue=9|pages=1465–79|pmid=27357601|doi=10.1111/jdv.13706}} External links{{Medical condition classification and resources| DiseasesDB = 34888 | ICD10 = {{ICD10|L|98|3|l|80}} (ILDS L98.300) | ICD9 = | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = }}
3 : Eosinophilic cutaneous conditions|Syndromes affecting the skin|Syndromes of unknown causes |
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