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词条 EPB41L1
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Band 4.1-like protein 1 is a protein that in humans is encoded by the EPB41L1 gene.[1][2][3]

Function

Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The protein encoded by this gene is a neuronally-enriched protein that is structurally similar to EPB41. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them has been determined.[3]

Interactions

EPB41L1 has been shown to interact with:

  • CENTG1,[4]
  • Dopamine receptor D2,[5]
  • Dopamine receptor D3,[5]
  • ITPR1,[6] and
  • Nuclear mitotic apparatus protein 1.[7]

References

1. ^{{cite journal | vauthors = Kim AC, Van Huffel C, Lutchman M, Chishti AH | title = Radiation hybrid mapping of EPB41L1, a novel protein 4.1 homologue, to human chromosome 20q11.2-q12 | journal = Genomics | volume = 49 | issue = 1 | pages = 165–6 | date = June 1998 | pmid = 9570967 | pmc = | doi = 10.1006/geno.1998.5212 }}
2. ^{{cite journal | vauthors = Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG | title = Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human | journal = Genomics | volume = 54 | issue = 2 | pages = 348–50 | date = January 1999 | pmid = 9828140 | pmc = | doi = 10.1006/geno.1998.5537 }}
3. ^1 {{cite web | title = Entrez Gene: EPB41L1 erythrocyte membrane protein band 4.1-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2036| accessdate = }}
4. ^{{cite journal | vauthors = Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH | title = Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N | journal = Cell | volume = 103 | issue = 6 | pages = 919–30 | date = December 2000 | pmid = 11136977 | doi = 10.1016/S0092-8674(00)00195-1}}
5. ^1 {{cite journal | vauthors = Binda AV, Kabbani N, Lin R, Levenson R | title = D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N | journal = Mol. Pharmacol. | volume = 62 | issue = 3 | pages = 507–13 | date = September 2002 | pmid = 12181426 | doi = 10.1124/mol.62.3.507}}
6. ^{{cite journal | vauthors = Maximov A, Tang TS, Bezprozvanny I | title = Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons | journal = Mol. Cell. Neurosci. | volume = 22 | issue = 2 | pages = 271–83 | date = February 2003 | pmid = 12676536 | doi = 10.1016/s1044-7431(02)00027-1}}
7. ^{{cite journal | vauthors = Ye K, Compton DA, Lai MM, Walensky LD, Snyder SH | title = Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor | journal = J. Neurosci. | volume = 19 | issue = 24 | pages = 10747–56 | date = December 1999 | pmid = 10594058 | doi = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P | title = New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. | journal = Front. Biosci. | volume = 11 | issue = | pages = 1646–66 | year = 2006 | pmid = 16368544 | doi = 10.2741/1911 }}
  • {{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. | journal = DNA Res. | volume = 4 | issue = 2 | pages = 141–50 | year = 1997 | pmid = 9205841 | doi = 10.1093/dnares/4.2.141 }}
  • {{cite journal | vauthors = Walensky LD, Blackshaw S, Liao D, Watkins CC, Weier HU, Parra M, Huganir RL, Conboy JG, Mohandas N, Snyder SH | title = A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1. | journal = J. Neurosci. | volume = 19 | issue = 15 | pages = 6457–67 | year = 1999 | pmid = 10414974 | doi = }}
  • {{cite journal | vauthors = Ye K, Compton DA, Lai MM, Walensky LD, Snyder SH | title = Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor. | journal = J. Neurosci. | volume = 19 | issue = 24 | pages = 10747–56 | year = 2000 | pmid = 10594058 | doi = }}
  • {{cite journal | vauthors = Shen L, Liang F, Walensky LD, Huganir RL | title = Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. | journal = J. Neurosci. | volume = 20 | issue = 21 | pages = 7932–40 | year = 2001 | pmid = 11050113 | doi = }}
  • {{cite journal | vauthors = Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH | title = Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. | journal = Cell | volume = 103 | issue = 6 | pages = 919–30 | year = 2001 | pmid = 11136977 | doi = 10.1016/S0092-8674(00)00195-1 }}
  • {{cite journal | vauthors = Binda AV, Kabbani N, Lin R, Levenson R | title = D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N. | journal = Mol. Pharmacol. | volume = 62 | issue = 3 | pages = 507–13 | year = 2002 | pmid = 12181426 | doi = 10.1124/mol.62.3.507 }}
  • {{cite journal | vauthors = Zhang S, Mizutani A, Hisatsune C, Higo T, Bannai H, Nakayama T, Hattori M, Mikoshiba K | title = Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells. | journal = J. Biol. Chem. | volume = 278 | issue = 6 | pages = 4048–56 | year = 2003 | pmid = 12444087 | pmc = 2366074 | doi = 10.1074/jbc.M209960200 }}
  • {{cite journal | vauthors = Coleman SK, Cai C, Mottershead DG, Haapalahti JP, Keinänen K | title = Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein. | journal = J. Neurosci. | volume = 23 | issue = 3 | pages = 798–806 | year = 2003 | pmid = 12574408 | doi = }}
  • {{cite journal | vauthors = Maximov A, Tang TS, Bezprozvanny I | title = Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons. | journal = Mol. Cell. Neurosci. | volume = 22 | issue = 2 | pages = 271–83 | year = 2003 | pmid = 12676536 | doi = 10.1016/S1044-7431(02)00027-1 }}
  • {{cite journal | vauthors = Nagaraja GM, Kandpal RP | title = Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. | journal = Biochem. Biophys. Res. Commun. | volume = 313 | issue = 3 | pages = 654–65 | year = 2004 | pmid = 14697242 | doi = 10.1016/j.bbrc.2003.12.001 }}
  • {{cite journal | vauthors = Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP | title = Phosphoproteomic analysis of the developing mouse brain. | journal = Mol. Cell. Proteomics | volume = 3 | issue = 11 | pages = 1093–101 | year = 2005 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 }}
  • {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
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