| 释义 |
- References
- Further reading
{{Infobox_gene}}EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.[1][2]This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.[3] References1. ^{{cite journal | last1 = Ephnomenclaturecommittee| title = Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee | journal = Cell | volume = 90 | issue = 3 | pages = 403–4 |date=Sep 1997 | pmid = 9267020 | pmc = | doi = 10.1016/S0092-8674(00)80500-0}}
2. ^{{cite web | title = Entrez Gene: EPHA1 EPH receptor A1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2041| accessdate = }}
3. ^{{cite web | title = Entrez Gene: EPHA1 EPH receptor A1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2041| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
- {{cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi= 10.1016/S0163-7258(97)00112-5}}
- {{cite journal | vauthors=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi= }}
- {{cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi= 10.1016/S0074-7696(00)96005-4}}
- {{cite journal | vauthors=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond. B Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 | pmc=1692797 |doi= 10.1098/rstb.2000.0635 }}
- {{cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi= 10.1038/35058515}}
- {{cite journal | vauthors=Hirai H, Maru Y, Hagiwara K |title=A novel putative tyrosine kinase receptor encoded by the eph gene. |journal=Science |volume=238 |issue= 4834 |pages= 1717–20 |year= 1988 |pmid= 2825356 |doi=10.1126/science.2825356 |display-authors=etal}}
- {{cite journal | vauthors=Gale NW, Holland SJ, Valenzuela DM |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi= 10.1016/S0896-6273(00)80276-7|display-authors=etal}}
- {{cite journal | vauthors=Owshalimpur D, Kelley MJ |title=Genomic structure of the EPHA1 receptor tyrosine kinase gene. |journal=Mol. Cell. Probes |volume=13 |issue= 3 |pages= 169–73 |year= 1999 |pmid= 10369740 |doi= 10.1006/mcpr.1999.0228 }}
- {{cite journal | vauthors=Kalo MS, Pasquale EB |title=Signal transfer by eph receptors |journal= Cell and Tissue Research|volume=298 |issue= 1 |pages= 1–9 |date=October 1999|pmid= 10502115 |doi= 10.1007/pl00008807}}
- {{cite journal | vauthors=Coulthard MG, Lickliter JD, Subanesan N |title=Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues. |journal=Growth Factors |volume=18 |issue= 4 |pages= 303–17 |year= 2002 |pmid= 11519828 |doi=10.3109/08977190109029118 |display-authors=etal}}
- {{cite journal | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
- {{cite journal | vauthors=Brandenberger R, Wei H, Zhang S |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=2041}}{{Tyrosine kinases}}{{Enzymes}}{{Growth factor receptor modulators}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-7-stub}} 1 : Tyrosine kinase receptors |