| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene.[1][2][3] Function This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.[3] Interactions EPH receptor A3 has been shown to interact with EFNB2[4][5] and EFNA5.[5][6] References 1. ^{{cite journal | vauthors = Boyd AW, Ward LD, Wicks IP, Simpson RJ, Salvaris E, Wilks A, Welch K, Loudovaris M, Rockman S, Busmanis I | title = Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line | journal = J Biol Chem | volume = 267 | issue = 5 | pages = 3262–7 | date = March 1992 | pmid = 1737782 | pmc = | doi = }}
2. ^{{cite journal | vauthors = Wicks IP, Wilkinson D, Salvaris E, Boyd AW | title = Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 5 | pages = 1611–5 | date = April 1992 | pmid = 1311845 | pmc = 48502 | doi = 10.1073/pnas.89.5.1611 }}
3. ^1 {{Cite web| title = Entrez Gene: EPHA3 EPH receptor A3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2042| accessdate = }}
4. ^{{cite journal | vauthors = Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ | title = Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases | journal = Mol. Immunol. | volume = 32 | issue = 16 | pages = 1197–205 | date = November 1995 | pmid = 8559144 | doi = 10.1016/0161-5890(95)00108-5 }}
5. ^1 {{cite journal | vauthors = Lackmann M, Mann RJ, Kravets L, Smith FM, Bucci TA, Maxwell KF, Howlett GJ, Olsson JE, Vanden Bos T, Cerretti DP, Boyd AW | title = Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor | journal = J. Biol. Chem. | volume = 272 | issue = 26 | pages = 16521–30 | date = June 1997 | pmid = 9195962 | doi = 10.1074/jbc.272.26.16521 }}
6. ^{{cite journal | vauthors = Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK | title = LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain | journal = Cytokine | volume = 9 | issue = 8 | pages = 540–9 | date = August 1997 | pmid = 9245480 | doi = 10.1006/cyto.1997.0199 }}
Further reading {{Refbegin| 2}}- {{cite journal | vauthors = Flanagan JG, Vanderhaeghen P | title = The ephrins and Eph receptors in neural development. | journal = Annu. Rev. Neurosci. | volume = 21 | issue = | pages = 309–45 | year = 1998 | pmid = 9530499 | doi = 10.1146/annurev.neuro.21.1.309 }}
- {{cite journal | vauthors = Zhou R | title = The Eph family receptors and ligands. | journal = Pharmacol. Ther. | volume = 77 | issue = 3 | pages = 151–81 | year = 1998 | pmid = 9576626 | doi = 10.1016/S0163-7258(97)00112-5 }}
- {{cite journal | vauthors = Ernst AF, Jurney WM, McLoon SC | title = Mechanisms involved in development of retinotectal connections: roles of Eph receptor tyrosine kinases, NMDA receptors and nitric oxide. | journal = Prog. Brain Res. | volume = 118 | issue = | pages = 115–31 | year = 1999 | pmid = 9932438 | doi = 10.1016/S0079-6123(08)63204-5 }}
- {{cite journal | vauthors = Holder N, Klein R | title = Eph receptors and ephrins: effectors of morphogenesis. | journal = Development | volume = 126 | issue = 10 | pages = 2033–44 | year = 1999 | pmid = 10207129 | doi = }}
- {{cite journal | vauthors = Wilkinson DG | title = Eph receptors and ephrins: regulators of guidance and assembly. | journal = Int. Rev. Cytol. | volume = 196 | issue = | pages = 177–244 | year = 2000 | pmid = 10730216 | doi = 10.1016/S0074-7696(00)96005-4 }}
- {{cite journal | vauthors = Xu Q, Mellitzer G, Wilkinson DG | title = Roles of Eph receptors and ephrins in segmental patterning. | journal = Philos. Trans. R. Soc. Lond. B Biol. Sci. | volume = 355 | issue = 1399 | pages = 993–1002 | year = 2001 | pmid = 11128993 | pmc = 1692797 | doi = 10.1098/rstb.2000.0635 }}
- {{cite journal | vauthors = Wilkinson DG | title = Multiple roles of EPH receptors and ephrins in neural development. | journal = Nat. Rev. Neurosci. | volume = 2 | issue = 3 | pages = 155–64 | year = 2001 | pmid = 11256076 | doi = 10.1038/35058515 }}
- {{cite journal | vauthors = Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Maraskovsky E | title = Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. | journal = EMBO J. | volume = 13 | issue = 16 | pages = 3757–62 | year = 1994 | pmid = 8070404 | pmc = 395287 | doi = }}
- {{cite journal | vauthors = Wicks IP, Lapsys NM, Baker E, Campbell LJ, Boyd AW, Sutherland GR | title = Localization of a human receptor tyrosine kinase (ETK1) to chromosome region 3p11.2. | journal = Genomics | volume = 19 | issue = 1 | pages = 38–41 | year = 1994 | pmid = 8188238 | doi = 10.1006/geno.1994.1009 }}
- {{cite journal | vauthors = Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ | title = Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases. | journal = Mol. Immunol. | volume = 32 | issue = 16 | pages = 1197–205 | year = 1996 | pmid = 8559144 | doi = 10.1016/0161-5890(95)00108-5 }}
- {{cite journal | vauthors = Lackmann M, Mann RJ, Kravets L, Smith FM, Bucci TA, Maxwell KF, Howlett GJ, Olsson JE, Vanden Bos T, Cerretti DP, Boyd AW | title = Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor. | journal = J. Biol. Chem. | volume = 272 | issue = 26 | pages = 16521–30 | year = 1997 | pmid = 9195962 | doi = 10.1074/jbc.272.26.16521 }}
- {{cite journal | vauthors = Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK | title = LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain. | journal = Cytokine | volume = 9 | issue = 8 | pages = 540–9 | year = 1997 | pmid = 9245480 | doi = 10.1006/cyto.1997.0199 }}
- {{cite journal | vauthors = Ephnomenclaturecommittee, | title = Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. | journal = Cell | volume = 90 | issue = 3 | pages = 403–4 | year = 1997 | pmid = 9267020 | doi = 10.1016/S0092-8674(00)80500-0 }}
- {{cite journal | vauthors = Lackmann M, Oates AC, Dottori M, Smith FM, Do C, Power M, Kravets L, Boyd AW | title = Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. | journal = J. Biol. Chem. | volume = 273 | issue = 32 | pages = 20228–37 | year = 1998 | pmid = 9685371 | doi = 10.1074/jbc.273.32.20228 }}
- {{cite journal | vauthors = Ciossek T, Monschau B, Kremoser C, Löschinger J, Lang S, Müller BK, Bonhoeffer F, Drescher U | title = Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. | journal = Eur. J. Neurosci. | volume = 10 | issue = 5 | pages = 1574–80 | year = 1998 | pmid = 9751130 | doi = 10.1046/j.1460-9568.1998.00180.x }}
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