释义 |
- References
- Further reading
{{Infobox_gene}}EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene.[1][2][3]This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.[4] References1. ^{{cite journal | last1 = Ephnomenclaturecommittee| title = Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee | journal = Cell | volume = 90 | issue = 3 | pages = 403–4 |date=Sep 1997 | pmid = 9267020 | pmc = | doi = 10.1016/S0092-8674(00)80500-0}} 2. ^{{cite journal | vauthors = Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT | title = A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12 | journal = Genomics | volume = 22 | issue = 2 | pages = 431–6 |date=Jan 1995 | pmid = 7528718 | pmc = | doi = 10.1006/geno.1994.1405 }} 3. ^{{cite web | title = Entrez Gene: EPHA5 EPH receptor A5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2044| accessdate = }} 4. ^{{cite web | title = Entrez Gene: EPHA5 EPH receptor A5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2044| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=Zhou R |title=Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands. |journal=Cell Tissue Res. |volume=290 |issue= 2 |pages= 251–9 |year= 1997 |pmid= 9321686 |doi=10.1007/s004410050929 }}
- {{cite journal | author=Caras IW |title=A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1. |journal=Cell Tissue Res. |volume=290 |issue= 2 |pages= 261–4 |year= 1997 |pmid= 9321687 |doi=10.1007/s004410050930 }}
- {{cite journal | vauthors=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
- {{cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=10.1016/S0163-7258(97)00112-5 }}
- {{cite journal | vauthors=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi= }}
- {{cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=10.1016/S0074-7696(00)96005-4 }}
- {{cite journal | vauthors=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond. B Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 | pmc=1692797 |doi= 10.1098/rstb.2000.0635 }}
- {{cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=10.1038/35058515 }}
- {{cite journal | vauthors=Fox GM, Holst PL, Chute HT |title=cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. |journal=Oncogene |volume=10 |issue= 5 |pages= 897–905 |year= 1995 |pmid= 7898931 |doi= |display-authors=etal}}
- {{cite journal | vauthors=Davis S, Gale NW, Aldrich TH |title=Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. |journal=Science |volume=266 |issue= 5186 |pages= 816–9 |year= 1994 |pmid= 7973638 |doi=10.1126/science.7973638 |display-authors=etal}}
- {{cite journal | vauthors=Gale NW, Holland SJ, Valenzuela DM |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=10.1016/S0896-6273(00)80276-7 |display-authors=etal}}
- {{cite journal | vauthors=Miescher GC, Taylor V, Olivieri G |title=Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors. |journal=Brain Res. Mol. Brain Res. |volume=46 |issue= 1-2 |pages= 17–24 |year= 1997 |pmid= 9191074 |doi=10.1016/S0169-328X(96)00268-9 |display-authors=etal}}
- {{cite journal | vauthors=Stein E, Savaskan NE, Ninnemann O |title=A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. |journal=J. Neurosci. |volume=19 |issue= 20 |pages= 8885–93 |year= 1999 |pmid= 10516308 |doi= |display-authors=etal}}
{{refend}}{{Tyrosine kinases}}{{Growth factor receptor modulators}}{{gene-4-stub}} |