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词条 Erbulozole
释义

  1. Synthesis

  2. References

  3. Other reading

{{Drugbox
| Watchedfields = changed
| verifiedrevid = 443731559
| IUPAC_name =
| image = Erbuzole structure.png
| width = 200
| tradename =
| pregnancy_category =
| legal_status =
| routes_of_administration =
| bioavailability =
| metabolism =
| excretion =
| CAS_number = 124784-31-2
| ATC_suffix =
| PubChem = 9934372
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID = 8110000
| synonyms = Erbuzole
| C=24 | H=27 | N=3 | O=5 | S=1
| molecular_weight = 469.55g/mol
| smiles = CCOC(=O)NC1=CC=C(C=C1)SC[C@H]2CO[C@](O2)(CN3C=CN=C3)C4=CC=C(C=C4)OC
| StdInChI = 1S/C24H27N3O5S/c1-3-30-23(28)26-19-6-10-22(11-7-19)33-15-21-14-31-24(32-21,16-27-13-12-25-17-27)18-4-8-20(29-2)9-5-18/h4-13,17,21H,3,14-16H2,1-2H3,(H,26,28)/t21-,24+/m1/s1
| StdInChIKey = KLEPCGBEXOCIGS-QPPBQGQZSA-N
}}Erbulozole (R55104) is a congener of the microtubule inhibitor tubulozole. It is undergoing phase I clinical trials as a chemotherapeutic agent.[1]

Synthesis

References

1. ^{{Cite journal| last1 = Van Belle| first1 = SJ| last2 = Distelmans| first2 = W| last3 = Vandebroek| first3 = J| last4 = Bruynseels| first4 = J| last5 = Van Ginckel| first5 = R| last6 = Storme| first6 = GA| title = Phase I trial of erbulozole (R55104)| journal = Anticancer Research| volume = 13| issue = 6B| pages = 2389–91| year = 1993| pmid = 8135472}}

Other reading

  • {{cite journal | author = Distelmans, W.; VanGinckel, P.; Heeres, J.; Van der Veken, L. J. E. |title=Erbulozole. Antineoplastic, Microtubule inhibitor| journal = Drugs Future | year = 1991 | volume = 16 | issue=6 | pages = 577}}
{{Intracellular chemotherapeutic agents}}{{Extracellular chemotherapeutic agents}}{{antineoplastic-drug-stub}}

1 : Experimental cancer drugs

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