| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}ELKS/RAB6-interacting/CAST family member 1 is a protein that in humans is encoded by the ERC1 gene.[1][2][3] The name ELKS is derived from "protein rich in the amino acids E, L, K and S"[4]The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene.[5] ELKS has been reported to direct vesicles with RAB6A to melanosomes.[4] InteractionsERC1 has been shown to interact with RAB6A.[2] References1. ^{{cite journal | vauthors = Yokota T, Nakata T, Minami S, Inazawa J, Emi M | title = Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma | journal = J Hum Genet | volume = 45 | issue = 1 | pages = 6–11 |date=Apr 2000 | pmid = 10697956 | pmc = | doi = 10.1007/s100380050002 }}
2. ^1 {{cite journal | vauthors = Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B | title = Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport | journal = Traffic | volume = 3 | issue = 4 | pages = 289–97 |date=Apr 2002 | pmid = 11929610 | pmc = | doi =10.1034/j.1600-0854.2002.030406.x }}
3. ^{{cite web | title = Entrez Gene: ERC1 ELKS/RAB6-interacting/CAST family member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23085| accessdate = }}
4. ^1 {{cite journal | vauthors = Patwardhan A, Bardin S, Miserey-Lenkei S, Larue L, Goud B, Raposo G, Delevoye C | title = Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes | journal = Nature Communications | volume = 8 | issue = | pages = 15835 | year = 2017 | pmid = 28607494 | doi = 10.1038/ncomms15835 | pmc=5474736}}
5. ^{{cite web | title = Entrez Gene: ERC1 ELKS/RAB6-interacting/CAST family member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23085| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
- {{cite journal | vauthors=Armour JA, Crosier M, Jeffreys AJ |title=Human minisatellite alleles detectable only after PCR amplification. |journal=Genomics |volume=12 |issue= 1 |pages= 116–24 |year= 1992 |pmid= 1733848 |doi=10.1016/0888-7543(92)90413-M }}
- {{cite journal | vauthors=Nakata T, Kitamura Y, Shimizu K |title=Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma. |journal=Genes Chromosomes Cancer |volume=25 |issue= 2 |pages= 97–103 |year= 1999 |pmid= 10337992 |doi=10.1002/(SICI)1098-2264(199906)25:2<97::AID-GCC4>3.0.CO;2-L |display-authors=etal}}
- {{cite journal | vauthors=Kikuno R, Nagase T, Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 |display-authors=etal}}
- {{cite journal | vauthors=Nakata T, Yokota T, Emi M, Minami S |title=Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma. |journal=Genes Chromosomes Cancer |volume=35 |issue= 1 |pages= 30–7 |year= 2002 |pmid= 12203787 |doi= 10.1002/gcc.10095 }}
- {{cite journal | vauthors=Wang Y, Liu X, Biederer T, Südhof TC |title=A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 22 |pages= 14464–9 |year= 2002 |pmid= 12391317 |doi= 10.1073/pnas.182532999 | pmc=137906 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Ko J, Na M, Kim S |title=Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42377–85 |year= 2004 |pmid= 12923177 |doi= 10.1074/jbc.M307561200 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E |title=CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST. |journal=Genes Cells |volume=9 |issue= 1 |pages= 15–23 |year= 2004 |pmid= 14723704 |doi=10.1111/j.1356-9597.2004.00697.x |display-authors=etal}}
- {{cite journal | vauthors=Ducut Sigala JL, Bottero V, Young DB |title=Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. |journal=Science |volume=304 |issue= 5679 |pages= 1963–7 |year= 2004 |pmid= 15218148 |doi= 10.1126/science.1098387 |display-authors=etal}}
- {{cite journal | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
- {{cite journal | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
- {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
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