| 释义 |
- References
- Further reading
{{Infobox_gene}}{{Infobox protein family
| Symbol = ER
| Name = Enhancer of rudimentary
| image = PDB 1wz7 EBI.jpg
| width =
| caption = crystal structure of enhancer of rudimentary homologue (erh)
| Pfam = PF01133
| Pfam_clan =
| InterPro = IPR000781
| SMART =
| PROSITE = PDOC00732
| MEROPS =
| SCOP = 1j24
| TCDB = 3.A.16
| OPM family =
| OPM protein =
| CAZy =
| CDD =
}}In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.[1][2][3] The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.[4] From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms.[2] It has been proposed that this protein plays a role in the cell cycle. References1. ^{{cite journal | vauthors = Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y | title = Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene | journal = Genomics | volume = 32 | issue = 1 | pages = 125–7 |date=Sep 1996 | pmid = 8786099 | pmc = | doi = 10.1006/geno.1996.0086 }}
2. ^1 {{cite journal | vauthors = Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI | title = The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals | journal = Gene | volume = 186 | issue = 2 | pages = 189–95 |date=Apr 1997 | pmid = 9074495 | pmc = | doi =10.1016/S0378-1119(96)00701-9 }}
3. ^{{cite web | title = Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2079| accessdate = }}
4. ^{{Cite journal | last1 = Wojcik | first1 = E. | last2 = Murphy | first2 = A. M. | last3 = Fares | first3 = H. | last4 = Dang-Vu | first4 = K. | last5 = Tsubota | first5 = S. I. | title = Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene | journal = Genetics | volume = 138 | issue = 4 | pages = 1163–1170 | year = 1994 | pmid = 7896098 | pmc = 1206255}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
- {{cite journal | vauthors=Amente S, Napolitano G, Licciardo P |title=Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 683–9 |year= 2005 |pmid= 15670829 |doi= 10.1016/j.febslet.2004.12.045 |display-authors=etal}}
- {{cite journal | vauthors=Wan C, Tempel W, Liu ZJ |title=Structure of the conserved transcriptional repressor enhancer of rudimentary homolog |journal=Biochemistry |volume=44 |issue= 13 |pages= 5017–23 |year= 2005 |pmid= 15794639 |doi= 10.1021/bi047785w |display-authors=etal}}
- {{cite journal | vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal}}
- {{cite journal | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
- {{cite journal | vauthors=Jin T, Guo F, Serebriiskii IG |title=A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks |journal=Proteins |volume=68 |issue= 2 |pages= 427–37 |year= 2007 |pmid= 17444515 |doi= 10.1002/prot.21343 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=2079}}{{InterPro content|IPR000781}}{{gene-14-stub}} 1 : Protein families |