| 词条 | Erythravine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 424873614 | ImageFile=Erythravine.png | ImageSize=200px | IUPACName= | OtherNames= |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo=19373-79-6 | PubChem = 11231853 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 9406901 | SMILES = COC1=C(C=C2C(=C1)CCN3[C@]24C[C@H](C=CC4=CC3)O)OC | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C18H21NO3/c1-21-16-9-12-5-7-19-8-6-13-3-4-14(20)11-18(13,19)15(12)10-17(16)22-2/h3-4,6,9-10,14,20H,5,7-8,11H2,1-2H3/t14-,18-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = JEBFJSHKHYDVNP-KSSFIOAISA-N |Section2={{Chembox Properties | C=18 | H=21 | N=1 | O=3 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Erythravine is a tetrahydroisoquinoline alkaloid found in the plant Erythrina mulungu and other species of the genus Erythrina. Biological activitySome laboratory research has investigated the biological activity of erythravine, but the relevance to effects in humans is unknown. Nicotinic acetylcholine receptorIt has been shown to be a potent nicotinic receptor antagonist in animal models with an IC50 of 6µM at the α7 site and 13 nM for the α4β2 receptor.[1] AnxiolyticIt appears to have anxiolytic effects in animal models of anxiety. Further studies suggest that the anxiolytic effects are only reproducible with the whole extract of Erythrina Mulungu but not with the pure alkaloids.[2][3] AnticonvulsantErythravine inhibited seizures evoked by bicuculline, pentylenetetrazole, and kainic acid as well as increasing the latency of seizures induced by NMDA. Treatment with erythravine prevented death in all the animals tested with the four convulsants except a few of those treated with kainic acid.[4] See alsoBark isolatesReferences1. ^{{Cite journal|last=Setti-Perdigão|first=Pedro|last2=Serrano|first2=Maria A. R.|last3=Flausino|first3=Otávio A.|last4=Bolzani|first4=Vanderlan S.|last5=Guimarães|first5=Marília Z. P.|last6=Castro|first6=Newton G.|date=2013-01-01|title=Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells|journal=PLoS One|volume=8|issue=12|pages=e82726|doi=10.1371/journal.pone.0082726|issn=1932-6203|pmc=3862643|pmid=24349349}} {{Nicotinic acetylcholine receptor modulators}}{{alkaloid-stub}}2. ^{{cite journal | last1 = Flausino Jr | first1 = O | last2 = Santos Lde | first2 = A | last3 = Verli | first3 = H | last4 = Pereira | first4 = AM | last5 = Bolzani Vda | first5 = S | last6 = Nunes-De-Souza | first6 = RL | title = Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu | journal = Journal of Natural Products | volume = 70 | issue = 1 | pages = 48–53 | year = 2007 | pmid = 17253849 | doi = 10.1021/np060254j }} 3. ^{{cite journal | last1 = Flausino Jr | first1 = OA | last2 = Pereira | first2 = AM | last3 = Da Silva Bolzani | first3 = V | last4 = Nunes-De-Souza | first4 = RL | title = Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety | journal = Biological & Pharmaceutical Bulletin | volume = 30 | issue = 2 | pages = 375–8 | year = 2007 | pmid = 17268084 | doi = 10.1248/bpb.30.375 }} 4. ^{{Cite journal|last=Faggion|first=Silmara Aparecida|last2=Cunha|first2=Alexandra Olimpio Siqueira|last3=Fachim|first3=Helene Aparecida|last4=Gavin|first4=Amanda Salomão|last5=dos Santos|first5=Wagner Ferreira|last6=Pereira|first6=Ana Maria Soares|last7=Beleboni|first7=Renê Oliveira|date=2011-03-01|title=Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae)|journal=Epilepsy & Behavior|volume=20|issue=3|pages=441–446|doi=10.1016/j.yebeh.2010.12.037|issn=1525-5069|pmid=21277832}} 7 : Tetrahydroisoquinolines|Phenol ethers|Alcohols|Anticonvulsants|Nicotinic antagonists|Anxiolytics|Alkaloids |
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