| 词条 | Ethanolamine-O-sulfate |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 424663738 | Reference = [1] | Name = Ethanolamine-O-sulfate | ImageFile = Ethanolamine-O-sulfate.svg | ImageSize = 170 | IUPACName = 2-Aminoethyl hydrogen sulfate | OtherNames = Aminoethyl sulfate; 2-Aminoethyl hydrogen sulphate; Sulfuric acid mono 2-aminoethyl ester; WAS-34 | Section1 = {{Chembox Identifiers | Abbreviations = EOS | CASNo_Ref = {{cascite|correct|??}} | CASNo = 926-39-6 | SMILES = C(COS(=O)(=O)O)N | PubChem = 5245535 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 63409 | InChI = 1/C2H7NO4S/c3-1-2-7-8(4,5)6/h1-3H2,(H,4,5,6) | InChIKey = WSYUEVRAMDSJKL-UHFFFAOYAA | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C2H7NO4S/c3-1-2-7-8(4,5)6/h1-3H2,(H,4,5,6) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = WSYUEVRAMDSJKL-UHFFFAOYSA-N | Section2 = {{Chembox Properties | C=2 | H=7 | N=1 | O=4 | S=1 | Appearance = | Density = | MeltingPtC = 277 | MeltingPt_notes = (decomposes) | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = | RPhrases = {{R22}} {{R36/37/38}} | SPhrases = {{S26}} {{S36}} }} Ethanolamine-O-sulfate (EOS) is an ester of sulfuric acid and ethanolamine. EOS is a GABA transaminase inhibitor which prevents the metabolism of GABA.[2] It is used as a biochemical tool in studies involving GABA. EOS is also a diuretic[3] and an anticonvulsant.[4] References1. ^2-Aminoethyl hydrogen sulfate at Sigma-Aldrich {{Anticonvulsants}}{{GABA metabolism and transport modulators}}2. ^{{cite journal |vauthors=Gudelsky GA, Apud JA, Masotto C, Locatelli V, Cocchi D, Racagni G, Muller EE |year=1983 |title=Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin concentrations |journal=Neuroendocrinology |volume=37 |issue=5 |pages=397–9 |doi=10.1159/000123580 |pmid=6646351}} 3. ^German Patent DE2345291: Diuretic aminoalkyl sulfates; Somani, Pitambar; Martin, Donald Lyons (1974) 4. ^{{cite journal |author1=Anlezark, Gill |author2=Horton, Roger W. |author3=Meldrum, Brian S. |author4=Sawaya, M. Christina B. |date=1976 |title=Anticonvulsant action of ethanolamine-O-sulfate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures |journal=Biochemical Pharmacology |volume=25 |issue=4 |pages=413–417 |doi=10.1016/0006-2952(76)90343-9 |pmid=779794}} 4 : Anticonvulsants|Diuretics|GABA transaminase inhibitors|Organosulfates |
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