| 词条 | Ethcathinone |
| 释义 |
| verifiedrevid = 448004046 | IUPAC_name = (RS)-2-ethylamino-1-phenyl-propan-1-one | image = Ethcathinone.svg | image2 = Ethcathinone molecule ball.png | width2 = 250px | alt2 = Ball-and-stick model of the ethcathinone molecule | chirality = Racemic mixture | tradename = | pregnancy_category = | legal_US = | legal_DE = Anlage II | legal_UK = Class B | routes_of_administration = oral, intranasal | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 7398 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 51553-17-4 | ATC_prefix = none | ATC_suffix = | PubChem = 458519 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 403504 | C=11 | H=15 | N=1 | O=1 | molecular_weight = 177.3 g/mol | melting_point = 195 | melting_high = 198 | melting_notes = (hydrochloride) | boiling_point = 272.3 | boiling_notes = at 760 mmHg (hydrochloride) | smiles = O=C(c1ccccc1)C(NCC)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C11H15NO/c1-3-12-9(2)11(13)10-7-5-4-6-8-10/h4-9,12H,3H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = LYMHIBZGTAPASQ-UHFFFAOYSA-N | synonyms = N-Ethylcathinone; 2-Ethylaminopropiophenone }}Ethcathinone, also known as ethylpropion or ETH-CAT, is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes. It is an active metabolite of the prodrug diethylcathinone and is fully responsible for its effects. Ethcathinone has been identified as an ingredient in both quasi-legal "party pills",[1] and, along with mephedrone, has also been reported as having been sold as "ecstasy" in the Australian city of Cairns.[2][3] PharmacologyThe pharmacology for ethcathinone appeared alongside other psychostimulants in a paper by Rothman and Baumann in 2006.[4] The predominant two modes of action for ethcathinone is as a moderately active releaser of noradrenaline (EC50 = 99.3nM);[4] however it is only a relatively weak inhibitor of dopamine reuptake (Ki = 1,014nM).[4] Since diethylcathinone appears to be an inactive prodrug and only becomes active after it has been further metabolized to ethcathinone,[4] it thereby would appear rational to consider that ethcathinone would also be expected to be N-dealkylated upon its consumption to the more active drug cathinone that is more able to reliably stimulate the release of dopamine. However, in contrast to diethylcathinone, ethcathinone is not universally considered to be a prodrug since (as is the case with tramadol, codeine, and MDMA) it is already active in its own right, therefore being excluded from the category by some of the more strict definitions. Legal statusEthcathinone, along with mephedrone and flephedrone, was banned in Denmark on December 18, 2008. As of October 2015 Ethcathinone is a controlled substance in China.[5] Ethyl cathinone is listed as a Schedule I Controlled Substance by the USDEA based on it being a positional isomer of mephedrone.[6] See also
References1. ^{{cite journal | last1 = Camilleri | first1 = A | last2 = Johnston | first2 = MR | last3 = Brennan | first3 = M | last4 = Davis | first4 = S | last5 = Caldicott | first5 = DG | title = Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone | journal = Forensic Science International | volume = 197 | issue = 1–3 | pages = 59–66 | year = 2010 | pmid = 20074881 | doi = 10.1016/j.forsciint.2009.12.048 }} {{Stimulants}}{{Monoamine releasing agents}}{{Phenethylamines}}2. ^[https://web.archive.org/web/20120208133936/http://www.cairns.com.au/article/2 Killer pills hit Cairns] 3. ^Police warn of potentially fatal 'fake ecstasy' 4. ^1 2 3 {{cite journal | last1 = Rothman | first1 = RB | last2 = Baumann | first2 = MH | title = Therapeutic potential of monoamine transporter substrates | journal = Current Topics in Medicinal Chemistry | volume = 6 | issue = 17 | pages = 1845–59 | year = 2006 | pmid = 17017961 | doi=10.2174/156802606778249766}} 5. ^{{cite web | url=http://www.sfda.gov.cn/WS01/CL0056/130753.html | title=关于印发《非药用类麻醉药品和精神药品列管办法》的通知 | publisher=China Food and Drug Administration | date=27 September 2015 | language=Chinese | accessdate=1 October 2015}} 6. ^DEA Controlled Substances Act listing dated 21-Jul-15 4 : Cathinones|Designer drugs|Norepinephrine-dopamine releasing agents|Stimulants |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。