“EXOC4”的意思、由来-开放百科全书

Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[3]

References

1. ^{{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 6 | pages = 347–55 | date = Feb 2001 | pmid = 11214970 | pmc = | doi = 10.1093/dnares/7.6.347 }}
2. ^¹²{{cite journal | vauthors = Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR | title = The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin | journal = Nature | volume = 422 | issue = 6932 | pages = 629–33 | date = Apr 2003 | pmid = 12687004 | pmc = | doi = 10.1038/nature01533 | url = https://deepblue.lib.umich.edu/bitstream/2027.42/62982/1/nature01533.pdf }}
3. ^¹{{cite web | title = Entrez Gene: EXOC4 exocyst complex component 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60412| accessdate = }}
4. ^¹²³⁴{{cite journal | vauthors = Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ | title = NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex | journal = Nat. Cell Biol. | volume = 5 | issue = 6 | pages = 520–30 | date = Jun 2003 | pmid = 12738960 | doi = 10.1038/ncb990 }}
5. ^{{cite journal | vauthors = Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL | title = Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor) | journal = Biochem. J. | volume = 373 | issue = Pt 1 | pages = 49–55 | date = Jul 2003 | pmid = 12675619 | pmc = 1223477 | doi = 10.1042/BJ20021838 }}

Further reading

{{cite journal | vauthors = Hsu SC, TerBush D, Abraham M, Guo W | title = The exocyst complex in polarized exocytosis. | journal = Int. Rev. Cytol. | volume = 233 | issue = | pages = 243–65 | year = 2004 | pmid = 15037366 | doi = 10.1016/S0074-7696(04)33006-8 }}

{{cite journal | vauthors = Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH | title = Subunit structure of the mammalian exocyst complex. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 26 | pages = 14438–43 | year = 1998 | pmid = 9405631 | pmc = 25013 | doi = 10.1073/pnas.94.26.14438 }}

{{cite journal | vauthors = Grindstaff KK, Yeaman C, Anandasabapathy N, Hsu SC, Rodriguez-Boulan E, Scheller RH, Nelson WJ | title = Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. | journal = Cell | volume = 93 | issue = 5 | pages = 731–40 | year = 1998 | pmid = 9630218 | doi = 10.1016/S0092-8674(00)81435-X }}

{{cite journal | vauthors = Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH | title = Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. | journal = Neuron | volume = 20 | issue = 6 | pages = 1111–22 | year = 1998 | pmid = 9655500 | doi = 10.1016/S0896-6273(00)80493-6 }}

{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination. | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}

{{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. | journal = EMBO Rep. | volume = 1 | issue = 3 | pages = 287–92 | year = 2001 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}

{{cite journal | vauthors = Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ | title = The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 29792–7 | year = 2001 | pmid = 11406615 | doi = 10.1074/jbc.C100320200 }}

{{cite journal | vauthors = Polzin A, Shipitsin M, Goi T, Feig LA, Turner TJ | title = Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. | journal = Mol. Cell. Biol. | volume = 22 | issue = 6 | pages = 1714–22 | year = 2002 | pmid = 11865051 | pmc = 135608 | doi = 10.1128/MCB.22.6.1714-1722.2002 }}

{{cite journal | vauthors = Vega IE, Hsu SC | title = The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells. | journal = NeuroReport | volume = 14 | issue = 1 | pages = 31–7 | year = 2003 | pmid = 12544826 | doi = 10.1097/01.wnr.0000050304.92401.50 }}

{{cite journal | vauthors = Riefler GM, Balasingam G, Lucas KG, Wang S, Hsu SC, Firestein BL | title = Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor). | journal = Biochem. J. | volume = 373 | issue = Pt 1 | pages = 49–55 | year = 2003 | pmid = 12675619 | pmc = 1223477 | doi = 10.1042/BJ20021838 }}

{{cite journal | vauthors = Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ | title = NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. | journal = Nat. Cell Biol. | volume = 5 | issue = 6 | pages = 520–30 | year = 2003 | pmid = 12738960 | doi = 10.1038/ncb990 }}

{{cite journal | vauthors = Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA | title = Ral GTPases regulate exocyst assembly through dual subunit interactions. | journal = J. Biol. Chem. | volume = 278 | issue = 51 | pages = 51743–8 | year = 2004 | pmid = 14525976 | doi = 10.1074/jbc.M308702200 }}

{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}

Function

Interactions

References

Further reading