| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.[1][2][3]This gene encodes a core component of the exosome complex. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.[4] InteractionsExosome component 1 has been shown to interact with: - Exosome component 5,[1][5]
- Exosome component 6,[5] and
- Exosome component 7.[1][5]
References1. ^1 2 {{cite journal |vauthors=Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ | title = Protein-protein interactions of hCsl4p with other human exosome subunits | journal = J Mol Biol | volume = 315 | issue = 4 | pages = 809–18 |date=Jan 2002 | pmid = 11812149 | pmc = | doi = 10.1006/jmbi.2001.5265 }}
2. ^{{cite journal |vauthors=Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M | title = AU binding proteins recruit the exosome to degrade ARE-containing mRNAs | journal = Cell | volume = 107 | issue = 4 | pages = 451–64 |date=Nov 2001 | pmid = 11719186 | pmc = | doi =10.1016/S0092-8674(01)00578-5 }}
3. ^{{cite web | title = Entrez Gene: EXOSC1 exosome component 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51013| accessdate = }}
4. ^{{cite web | title = Entrez Gene: EXOSC1 exosome component 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51013| accessdate = }}
5. ^1 2 {{cite journal | date = Nov 2002 |vauthors=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ | title = Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring | journal = J. Mol. Biol. | volume = 323 | issue = 4 | pages = 653–63 | pmid = 12419256 | doi = 10.1016/s0022-2836(02)00947-6}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Lai CH, Chou CY, Ch'ang LY |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 | pmc=310876 |doi=10.1101/gr.10.5.703 |display-authors=etal}}
- {{cite journal |vauthors=van Hoof A, Staples RR, Baker RE, Parker R |title=Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8230–43 |year= 2000 |pmid= 11027292 | pmc=86432 |doi=10.1128/MCB.20.21.8230-8243.2000 }}
- {{cite journal |vauthors=Brouwer R, Allmang C, Raijmakers R |title=Three novel components of the human exosome. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6177–84 |year= 2001 |pmid= 11110791 |doi= 10.1074/jbc.M007603200 |display-authors=etal}}
- {{cite journal |vauthors=Brouwer R, Vree Egberts WT, Hengstman GJ |title=Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. |journal=Arthritis Res. |volume=4 |issue= 2 |pages= 134–8 |year= 2002 |pmid= 11879549 | pmc=83843 |doi=10.1186/ar389 |display-authors=etal}}
- {{cite journal |vauthors=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. |journal=J. Mol. Biol. |volume=323 |issue= 4 |pages= 653–63 |year= 2002 |pmid= 12419256 |doi=10.1016/S0022-2836(02)00947-6 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 |display-authors=etal}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal |vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
- {{cite journal |vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 | pmc=442147 |doi= 10.1101/gr.2122004 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 | pmc=528928 |doi= 10.1101/gr.2596504 |display-authors=etal}}
- {{cite journal |vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 | pmc=1356129 |doi= 10.1101/gr.4039406 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=51013}}{{gene-10-stub}} |