| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene.[1][2] Function Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions. In yeast, 3-prime-to-5-prime mRNA degradation is mediated by the exosome, a multisubunit particle. EXOSC2 (which is homologous to the yeast Rrp4 protein) is a component of the human exosome.[3] Interactions Exosome component 2 has been shown to interact with: - Exosome component 4,[4] and
- Exosome component 7.[4]
References 1. ^{{cite web | title = Entrez Gene: EXOSC2 exosome component 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23404| accessdate = }}
2. ^{{cite journal |vauthors=Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D | title = The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases | journal = Cell | volume = 91 | issue = 4 | pages = 457–66 |date=November 1997 | pmid = 9390555 | doi = 10.1016/S0092-8674(00)80432-8 | url = }}
3. ^{{cite journal |vauthors=Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M | title = AU binding proteins recruit the exosome to degrade ARE-containing mRNAs | journal = Cell | volume = 107 | issue = 4 | pages = 451–64 |date=November 2001 | pmid = 11719186 | doi = 10.1016/S0092-8674(01)00578-5 | url = }}
4. ^1 {{cite journal | date = Nov 2002 |vauthors=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ | title = Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring | journal = J. Mol. Biol. | volume = 323 | issue = 4 | pages = 653–63 | pmid = 12419256 | doi = 10.1016/s0022-2836(02)00947-6}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Adams MD, Dubnick M, Kerlavage AR |title=Sequence identification of 2,375 human brain genes. |journal=Nature |volume=355 |issue= 6361 |pages= 632–4 |year= 1992 |pmid= 1538749 |doi= 10.1038/355632a0 |display-authors=etal}}
- {{cite journal |vauthors=Morris CM, Heisterkamp N, Groffen J, Fitzgerald PH |title=Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia. |journal=Blood |volume=78 |issue= 4 |pages= 1078–84 |year= 1991 |pmid= 1868241 |doi= }}
- {{cite journal |vauthors=Zhu QS, Heisterkamp N, Groffen J |title=Characterization of the human ABL promoter regions. |journal=Oncogene |volume=5 |issue= 6 |pages= 885–91 |year= 1990 |pmid= 2163052 |doi= }}
- {{cite journal |vauthors=Soekarman D, van Denderen J, Hoefsloot L |title=A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia. |journal=Leukemia |volume=4 |issue= 6 |pages= 397–403 |year= 1990 |pmid= 2193202 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Chen SJ, Chen Z, Font MP |title=Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation. |journal=Nucleic Acids Res. |volume=17 |issue= 19 |pages= 7631–42 |year= 1989 |pmid= 2678002 |doi=10.1093/nar/17.19.7631 | pmc=334872 |display-authors=etal}}
- {{cite journal |vauthors=Heisterkamp N, Stam K, Groffen J |title=Structural organization of the bcr gene and its role in the Ph' translocation. |journal=Nature |volume=315 |issue= 6022 |pages= 758–61 |year= 1985 |pmid= 2989703 |doi=10.1038/315758a0 |display-authors=etal}}
- {{cite journal |vauthors=Shtivelman E, Lifshitz B, Gale RP |title=Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene. |journal=Cell |volume=47 |issue= 2 |pages= 277–84 |year= 1986 |pmid= 3021337 |doi=10.1016/0092-8674(86)90450-2 |display-authors=etal}}
- {{cite journal |vauthors=Grosveld G, Verwoerd T, van Agthoven T |title=The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript. |journal=Mol. Cell. Biol. |volume=6 |issue= 2 |pages= 607–16 |year= 1987 |pmid= 3023859 |doi= | pmc=367552 |display-authors=etal}}
- {{cite journal |vauthors=Bernards A, Rubin CM, Westbrook CA |title=The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia. |journal=Mol. Cell. Biol. |volume=7 |issue= 9 |pages= 3231–6 |year= 1987 |pmid= 3313010 |doi= | pmc=367959 |display-authors=etal}}
- {{cite journal |vauthors=Groffen J, Heisterkamp N, Grosveld F |title=Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. |journal=Science |volume=216 |issue= 4550 |pages= 1136–8 |year= 1982 |pmid= 6281890 |doi=10.1126/science.6281890 |display-authors=etal}}
- {{cite journal |vauthors=Heisterkamp N, Groffen J, Stephenson JR |title=The human v-abl cellular homologue. |journal=J. Mol. Appl. Genet. |volume=2 |issue= 1 |pages= 57–68 |year= 1983 |pmid= 6302194 |doi= }}
- {{cite journal |vauthors=Heisterkamp N, Stephenson JR, Groffen J |title=Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. |journal=Nature |volume=306 |issue= 5940 |pages= 239–42 |year= 1984 |pmid= 6316147 |doi=10.1038/306239a0 |display-authors=etal}}
- {{cite journal |vauthors=Groffen J, Stephenson JR, Heisterkamp N |title=Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. |journal=Cell |volume=36 |issue= 1 |pages= 93–9 |year= 1984 |pmid= 6319012 |doi=10.1016/0092-8674(84)90077-1 |display-authors=etal}}
- {{cite journal |vauthors=Chissoe SL, Bodenteich A, Wang YF |title=Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. |journal=Genomics |volume=27 |issue= 1 |pages= 67–82 |year= 1995 |pmid= 7665185 |doi=10.1006/geno.1995.1008 |display-authors=etal}}
- {{cite journal |vauthors=Litz CE, McClure JS, Copenhaver CM, Brunning RD |title=Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia. |journal=Blood |volume=81 |issue= 6 |pages= 1567–72 |year= 1993 |pmid= 8453102 |doi= }}
- {{cite journal |vauthors=Mitchell P, Petfalski E, Tollervey D |title=The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism. |journal=Genes Dev. |volume=10 |issue= 4 |pages= 502–13 |year= 1996 |pmid= 8600032 |doi=10.1101/gad.10.4.502 }}
- {{cite journal |vauthors=Mitchell P, Petfalski E, Shevchenko A |title=The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. |journal=Cell |volume=91 |issue= 4 |pages= 457–66 |year= 1997 |pmid= 9390555 |doi=10.1016/S0092-8674(00)80432-8 |display-authors=etal}}
- {{cite journal |vauthors=Allmang C, Petfalski E, Podtelejnikov A |title=The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. |journal=Genes Dev. |volume=13 |issue= 16 |pages= 2148–58 |year= 1999 |pmid= 10465791 |doi=10.1101/gad.13.16.2148 | pmc=316947 |display-authors=etal}}
- {{cite journal |vauthors=Brouwer R, Allmang C, Raijmakers R |title=Three novel components of the human exosome. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6177–84 |year= 2001 |pmid= 11110791 |doi= 10.1074/jbc.M007603200 |display-authors=etal}}
- {{cite journal |vauthors=Chen CY, Gherzi R, Ong SE |title=AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. |journal=Cell |volume=107 |issue= 4 |pages= 451–64 |year= 2002 |pmid= 11719186 |doi=10.1016/S0092-8674(01)00578-5 |display-authors=etal}}
{{refend}}{{PDB Gallery|geneid=23404}}{{gene-9-stub}} |